INT25121

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Context Info
Confidence 0.24
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.32
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
myocardium 2
PRP 2
tunica albuginea 2
platelets 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 100.00 Very High Very High Very High
aspirin 9 99.52 Very High Very High Very High
Gabapentin 8 98.94 Very High Very High Very High
Paracetamol 13 98.10 Very High Very High Very High
agonist 2 93.56 High High
fibrosis 72 89.20 High High
Serotonin 1 84.96 Quite High
gABA 1 81.12 Quite High
5HT 1 75.56 Quite High
cytokine 5 73.52 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 4 98.98 Very High Very High Very High
Reprotox - General 2 53 93.84 High High
Keloid Scars 1 92.96 High High
Aging 5 89.36 High High
Internal Fibrosis 1 89.20 High High
Fibrosis 9 86.08 High High
Partial Seizures 1 82.88 Quite High
Pulmonary Fibrosis 65 82.48 Quite High
Pulmonary Disease 3 70.72 Quite High
Hyperplasia 2 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gabapentin (120 and 240 microM) also concentration-dependently inhibited collagen (1 microg mL(-1))-induced phosphoinositide breakdown, intracellular Ca(2+) mobilization, thromboxane A(2) formation, and p38 MAPK phosphorylation in human platelets.
Negative_regulation (inhibited) of Positive_regulation (-induced) of collagen in platelets associated with gabapentin
1) Confidence 0.24 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883897 Disease Relevance 0.08 Pain Relevance 0.75
In PRP obtained 1 hour after ingestion of 650 mg or 1000 mg APAP, arachidonate-induced TxB2 formation was inhibited by 40-99% in five subjects tested, whereas inhibition of collagen- or epinephrine-induced TxB2 formation was less consistent.
Negative_regulation (inhibition) of Positive_regulation (epinephrine-induced) of collagen in PRP associated with paracetamol
2) Confidence 0.18 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 1.03
Blockade of TXA(2) production by aspirin results in significant inhibition of collagen activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of collagen associated with aspirin
3) Confidence 0.10 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 15583748 Disease Relevance 0.05 Pain Relevance 0.27
Also, osteopontin expression is increased in the myocardium after myocardial infarction, and the lack of this mediator is associated with decreased collagen accumulation [25].
Negative_regulation (decreased) of Positive_regulation (accumulation) of collagen in myocardium associated with myocardial infarction
4) Confidence 0.05 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.79 Pain Relevance 0.27
Systemic changes and alterations in the structure and function of the penis in elderly men include hormonal changes (mainly testosterone decrease and increase in sex hormone binding globulin that resulting decreased bioavailability of testosterone) (Margolese 2000), decrease in elastic fibers and increase in collagen fibers in the tunica albuginea (Akkus et al 1997) and molecular changes (decrease in nitric oxide synthase) (Andrew and Mayer 1999).
Negative_regulation (decrease) of Positive_regulation (increase) of collagen in tunica albuginea associated with bioavailability
5) Confidence 0.03 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699643 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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