INT25122

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Context Info
Confidence 0.31
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 13.83
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
osteoclasts 2
small intestine 2
cartilage 1
colon 1
fibroblast 1
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 53 99.70 Very High Very High Very High
Paracetamol 23 99.46 Very High Very High Very High
Inflammation 366 98.96 Very High Very High Very High
Osteoarthritis 145 98.70 Very High Very High Very High
antagonist 49 92.72 High High
cytokine 264 91.72 High High
metalloproteinase 345 88.08 High High
cINOD 125 87.60 High High
COX2 12 80.16 Quite High
COX-2 inhibitor 238 80.08 Quite High
Disease Link Frequency Relevance Heat
Fever 130 100.00 Very High Very High Very High
Herpes Simplex Virus 476 99.84 Very High Very High Very High
Hypercalcemia 42 99.80 Very High Very High Very High
Apoptosis 551 99.78 Very High Very High Very High
Targeted Disruption 37 99.36 Very High Very High Very High
Asthma 71 99.28 Very High Very High Very High
Cancer 704 99.00 Very High Very High Very High
INFLAMMATION 434 98.96 Very High Very High Very High
Breast Cancer 95 98.80 Very High Very High Very High
Osteoarthritis 172 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a case-controlled study of 63 candidate genes in a Japanese population,26 a functional SNP of the PGE2 receptor subtype 2 gene (EP2) was found to be associated with the risk of AIA.
EP2 Binding (associated) of associated with asthma
1) Confidence 0.31 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.63 Pain Relevance 0.09
Here we tested the hypothesis that PGE2 is associated with the suppressive effects of TGF-?
PGE2 Binding (associated) of
2) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.85 Pain Relevance 0.05
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-?

PGE2 Binding (Prostaglandin) of in articular cartilage associated with hypertrophy and osteoarthritis
3) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206385 Disease Relevance 0.74 Pain Relevance 0.04
Using HCT-116 cell line as a model to reflect the effect on mouse small intestine, it has been shown that the anti-apoptotic effect of dmPGE2, which is known to bind EP2, was tightly related to AKT phosphorylation through activation of EGFR and leads to an inhibition of Bax translocation in mitochondria, an important step for apoptosis [51].
EP2 Binding (bind) of in small intestine associated with apoptosis
4) Confidence 0.17 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.20 Pain Relevance 0.03
Using HCT-116 cell line as a model to reflect the effect on mouse small intestine, it has been shown that the anti-apoptotic effect of dmPGE2, which is known to bind EP2, was tightly related to AKT phosphorylation through activation of EGFR and leads to an inhibition of Bax translocation in mitochondria, an important step for apoptosis [51].
dmPGE2 Binding (bind) of in small intestine associated with apoptosis
5) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.21 Pain Relevance 0.03
According to such a scenario, and within the context of colon cancerogenesis, PGE2 signalling via EP3 could be a priming step for CRC cell mitogenesis that becomes shut off at later time points as aberrant proliferation takes over.


PGE2 Binding (signalling) of in colon associated with colon cancer
6) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.56 Pain Relevance 0.03
Several studies document that PGE2 engages proliferative or anti-apoptotic pathways via an increase in cAMP levels [33,50].
PGE2 Binding (engages) of associated with apoptosis
7) Confidence 0.13 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.30 Pain Relevance 0
PGE2 exerts its biological functions via binding to four types of G-protein-coupled receptors termed EP1-4 [13,14], which couple to distinct downstream second messenger systems.
PGE2 Binding (binding) of
8) Confidence 0.13 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.53 Pain Relevance 0.23
In this cell type, PGE2 is associated with an increase of cAMP through EP4 receptor.
PGE2 Binding (associated) of associated with fever
9) Confidence 0.12 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.86 Pain Relevance 0.05
In washed platelet suspensions labeled with 3H-arachidonate, both APAP and aspirin inhibited the formation of labeled PGD2 and PGE2, as well as TxB2.
PGE2 Binding (formation) of in platelet associated with aspirin and paracetamol
10) Confidence 0.10 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 0.96
After incubation, the Amerlex-M reagent is added and the free and bound 125I labeled PGE2 separated using centrifugation.
PGE2 Binding (bound) of
11) Confidence 0.07 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.27 Pain Relevance 0.16
In conclusion, OA cartilage was shown to respond to leptin by producing increased amounts of NO, PGE2, IL-6, IL-8, and all those effects can be considered harmful in cartilage metabolism.
PGE2 Neg (NO) Binding (amounts) of in cartilage associated with osteoarthritis
12) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.46 Pain Relevance 0.32
Therefore, in the second example by Accomazzo et al, with a = b Fig 9D, a possible interpretation of the PGE2-dependent reverse bell-shaped dose-response seems to be that, by dimerization of two PGE2 subtype receptors, the affinities at the two binding sites are dramatically altered, as the fitted value of parameter AM has to be nearly 5000 fold higher than AS to accommodate theory to experimental data, Fig 9D.
PGE2 Binding (dimerization) of
13) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0
When focusing on the delineation of a physiologically-relevant function for this high-affinity association, hrNuc specifically increased the COX-2-mediated formation of PGE2, in three distinct settings: purified COX-2, cell lysates, and transfected intact cells.
PGE2 Binding (formation) of
14) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0 Pain Relevance 0
Significant detection of COX-2 in KS lesions (Figure 1A, B and C), long term KSHV infected endothelial cells (Figure 2) and in de novo infection of endothelial and fibroblast cells [26], as well as modulation of viral gene expression by COX inhibition (Figures 1 and 2), strongly indicated a role for COX-2/PGE2 in KSHV pathogenesis.


PGE2 Binding (role) of in fibroblast associated with sarcoma, herpes simplex virus and infection
15) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.79 Pain Relevance 0.19
Addition of 50 ng/ml PGE2 completely restored channel formation in cells treated with 40 ?
PGE2 Binding (formation) of
16) Confidence 0.04 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.14 Pain Relevance 0
To determine whether celecoxib-induced inhibition of channel formation could be abrogated by adding exogenous PGE2, MDA-MB-231 cells were treated with 40 ?
PGE2 Binding (adding) of in MDA-MB-231
17) Confidence 0.04 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.07 Pain Relevance 0
The optimal dose of exogenous PGE2 was determined by titrating doses (25, 50, 100, 200, 400, 800, 1600, 3200, and 6400 ng/ml) of PGE2 with 40 ?
PGE2 Spec (determined) Binding (titrating) of
18) Confidence 0.04 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.28 Pain Relevance 0.04
Nuc can associate with COX-2 with high affinity and increase the resulting PGE2 generation.
PGE2 Binding (generation) of
19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0 Pain Relevance 0.03
High levels of PGE2 and IL6 are associated with bone resorption and osteoclast recruitment and stimulation [18,19].
PGE2 Binding (associated) of in osteoclast associated with hypercalcemia
20) Confidence 0.03 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0.59 Pain Relevance 0.26

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