INT25123

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 19.98
Pain Relevance 5.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
platelet 7
fibroblasts 3
skin 3
PRP 1
TMJ 1
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
Analgesic 5 99.84 Very High Very High Very High
aspirin 23 99.78 Very High Very High Very High
cINOD 12 99.52 Very High Very High Very High
Inflammation 74 99.32 Very High Very High Very High
Snapping jaw 18 99.16 Very High Very High Very High
adenocard 1 99.08 Very High Very High Very High
cva 17 98.88 Very High Very High Very High
metalloproteinase 14 98.50 Very High Very High Very High
Paracetamol 19 98.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteogenesis Imperfecta 2 100.00 Very High Very High Very High
Aging 117 99.96 Very High Very High Very High
Syndrome 26 99.76 Very High Very High Very High
Contracture 2 99.74 Very High Very High Very High
Injury 209 99.48 Very High Very High Very High
Keloid Scars 5 99.40 Very High Very High Very High
INFLAMMATION 87 99.32 Very High Very High Very High
Frailty 15 99.32 Very High Very High Very High
Temporomandibular Joint Syndrome 18 99.16 Very High Very High Very High
Hemorrhage 18 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the second study, a significant decrease of ADP (54 +/- 13% vs. 38 +/- 9%, P < 0.05), AA (76 +/- 16% vs. 22 +/- 14%, P < 0.05), and Collagen (66 +/- 13% vs. 37 +/- 11%, P < 0.05) induced platelet aggregation was observed at MOMENT d compared to the beginning of surgery in the CPB group.
Negative_regulation (decrease) of Collagen in platelet
1) Confidence 0.58 Published 2005 Journal Artif Organs Section Abstract Doc Link 15982282 Disease Relevance 0.07 Pain Relevance 0.09
Intrinsic aging processes include loss of skin elasticity and collagen, along with fat atrophy.
Negative_regulation (loss) of collagen in skin associated with aging and frailty
2) Confidence 0.51 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2695163 Disease Relevance 0.69 Pain Relevance 0.04
Type 1 collagen loss in the dermis is one of the primary causes of wrinkles seen in aged skin.
Negative_regulation (loss) of collagen in skin associated with wrinkles
3) Confidence 0.47 Published 2004 Journal Facial Plast Surg Section Abstract Doc Link 15643578 Disease Relevance 0.33 Pain Relevance 0.07
Ultramicroscopic examination of the mesh showed breakdown of the fibers, collagen reduction, and no chronic inflammatory cells.
Negative_regulation (reduction) of collagen associated with inflammation
4) Confidence 0.43 Published 1998 Journal Surg Endosc Section Abstract Doc Link 9569371 Disease Relevance 0.59 Pain Relevance 0.18
Vitamins and analgesics in the prevention of collagen ageing.
Negative_regulation (prevention) of collagen associated with aspirin, aging and analgesic
5) Confidence 0.42 Published 1996 Journal Age Ageing Section Title Doc Link 8831872 Disease Relevance 0.71 Pain Relevance 0.18
Aspirin-like compounds and certain vitamins successfully prevented the sugar-induced molecular changes from occurring in corneal and scleral collagen, suggesting that such compounds could have a useful role in this aspect of ageing.
Negative_regulation (prevented) of collagen associated with aspirin and aging
6) Confidence 0.42 Published 1996 Journal Age Ageing Section Abstract Doc Link 8831872 Disease Relevance 0.73 Pain Relevance 0.12
Three types of morphologic changes were found to alter the crimping morphology of collagen: 1) encircling layers of unusual matrix disrupted the lamellar collagen architecture; 2) collagen fibers were reduced in amount, and 3) collagen was absent in regions with focal matrix loss.


Negative_regulation (reduced) of collagen
7) Confidence 0.42 Published 2002 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC101374 Disease Relevance 0.31 Pain Relevance 0
In the present work, study of a collection of disc specimens from control and surgical patients has shown that the architectural features of collagen crimping in the annulus can be disrupted in three fashions.
Negative_regulation (disrupted) of collagen in annulus
8) Confidence 0.42 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.41 Pain Relevance 0
In these regions collagen fibers are fewer in number and fibers are separated from each other reducing collagen crimping areas.
Negative_regulation (reducing) of collagen
9) Confidence 0.42 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.08 Pain Relevance 0
Flupirtine was found to inhibit dose-dependently the collagen - but not the primary adenosine diphosphate-induced aggregation of human platelets, being again 1 order of magnitude less potent than indometacin (IC50: 4.0 vs. 0.6 mumol/l).
Negative_regulation (inhibit) of collagen in platelets associated with adenocard
10) Confidence 0.42 Published 1985 Journal Arzneimittelforschung Section Abstract Doc Link 3885962 Disease Relevance 0.06 Pain Relevance 0.13
Collagen deposition (UTC)
Negative_regulation (deposition) of Collagen
11) Confidence 0.41 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.07 Pain Relevance 0
The collagen building blocks, proline and hydroxyproline were also measured in CHIK patients and observed higher excretion compared to healthy controls.
Negative_regulation (blocks) of collagen
12) Confidence 0.41 Published 2008 Journal Virol J Section Abstract Doc Link PMC2291039 Disease Relevance 0.73 Pain Relevance 0.08
Decrease of the type III collagen was related to decrease of the tissue elasticity and increase of the tissue firmness.
Negative_regulation (Decrease) of collagen
13) Confidence 0.37 Published 1985 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 4054826 Disease Relevance 1.62 Pain Relevance 0.32
Collagen metabolism (PIIIP)
Negative_regulation (metabolism) of Collagen
14) Confidence 0.36 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.79 Pain Relevance 0.13
This reduction in collagen birefringence evidences that the relaxation attained by the interpubic joint at parturition is attributable, at least in part; to an active collagen remodeling process that facilitates a transformation from hard and unyielding to soft, swollen and flexible structure.
Negative_regulation (reduction) of collagen in joint
15) Confidence 0.34 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.09 Pain Relevance 0
Some individuals paradoxically display a tendency to form keloids and contractures despite the deficiency of collagen [3].
Negative_regulation (deficiency) of collagen associated with contracture and keloid scars
16) Confidence 0.33 Published 2010 Journal Cases J Section Body Doc Link PMC2829519 Disease Relevance 1.35 Pain Relevance 0.17
Tissue friability is also noted by many operating surgeons on patients with Ehlers Danlos syndrome due to the collagen deficiency.
Negative_regulation (deficiency) of collagen associated with syndrome and osteogenesis imperfecta
17) Confidence 0.33 Published 2010 Journal Cases J Section Body Doc Link PMC2829519 Disease Relevance 1.06 Pain Relevance 0.08
This suggests that a decrease in prolidase activity may contribute to a decrease in the biosynthesis of proline-containing proteins, such as collagen and SOS.
Negative_regulation (decrease) of collagen
18) Confidence 0.27 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Non-steroid anti-inflammatory drugs (NSAIDs) are known inhibitors of collagen biosynthesis in animal tissues and cell cultures.
Negative_regulation (inhibitors) of collagen in animal tissues associated with inflammation and cinod
19) Confidence 0.27 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.10 Pain Relevance 0.27
Acetylsalicylic acid-dependent inhibition of collagen biosynthesis and beta1-integrin signaling in cultured fibroblasts.
Negative_regulation (inhibition) of collagen in fibroblasts associated with aspirin
20) Confidence 0.27 Published 2004 Journal Med. Sci. Monit. Section Title Doc Link 15173663 Disease Relevance 0.10 Pain Relevance 0.33

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