INT251238

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 29.41
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 3
T cell 3
macrophages 2
lymphocytes 2
A549 2
Lvs (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 511 99.60 Very High Very High Very High
Inflammatory response 74 95.88 Very High Very High Very High
Inflammation 133 91.04 High High
chemokine 66 89.08 High High
depression 1 79.56 Quite High
anesthesia 34 78.04 Quite High
agonist 3 70.72 Quite High
Inflammatory mediators 3 68.88 Quite High
Central nervous system 2 56.24 Quite High
ketamine 18 53.84 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 2426 100.00 Very High Very High Very High
Infection 2335 100.00 Very High Very High Very High
Myotonic Dystrophy 22 100.00 Very High Very High Very High
Francisella Infection 747 99.98 Very High Very High Very High
Death 213 99.52 Very High Very High Very High
Immunization 49 99.32 Very High Very High Very High
Targeted Disruption 108 98.80 Very High Very High Very High
Bacterial Infection 24 98.64 Very High Very High Very High
Cleft Palate 1 96.40 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results suggest that CD4+ cells are the major contributors to IL-17A production in infected LVS lungs, yet ??
Gene_expression (production) of LVS in lungs associated with sprains and strains
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.54 Pain Relevance 0
Representative lung sections from untreated mice (Figure 3A) as well as sections from lungs of mice vaccinated intranasally with LPS alone (Figure 3B), LPS+rPorB (Figure 3, C and D) and LPS+rPorB without LVS challenge (Figure 3E) are reported.
Gene_expression (challenge) of LVS in lungs associated with sprains and strains
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.51 Pain Relevance 0.13
As mentioned above, infection with LVS alone also induced accumulation of lymphocytes around bronchi [40], but after IF staining we observed a lower cellular organization of the areas (data not shown).
Gene_expression (infection) of LVS in lymphocytes associated with sprains and strains and infection
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.80 Pain Relevance 0.07
Briefly, plate wells were coated with LPS from F. tularensis LVS (0.25 µg/ml), incubated at 37°C and stored overnight at 4°C.
Gene_expression (coated) of LVS associated with sprains and strains
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.52 Pain Relevance 0.18
A high percentage of mice vaccinated with LPS and PorB were significantly protected against lethal respiratory LVS infection when compared with the control groups, and presented well-organized bronchus-associated lymphoid tissue (BALT) in peribronchial and perivascular areas of their lungs.
Gene_expression (infection) of LVS in lungs associated with sprains and strains and infection
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.53 Pain Relevance 0.04
Sixty percent of the mice (6 out of 10) immunized with the LPS+rPorB were protected from challenge with 106 CFU of LVS, compared with the PBS control group that succumbed to tularemia within 8 days post-infection (Figure 2A).
Gene_expression (protected) of LVS associated with sprains and strains, infection and francisella infection
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.70 Pain Relevance 0
Intranasal LVS infection triggers a robust production of IL-17A by specific pulmonary T cell subpopulations
Gene_expression (infection) of LVS in T cell associated with sprains and strains and infection
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.13 Pain Relevance 0.19
In order to directly test the in vivo role of IL-17A in the response to sub-lethal LVS infection, IL-17A was depleted in vivo using anti-IL17A antibodies.
Gene_expression (infection) of LVS associated with sprains and strains and infection
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.04 Pain Relevance 0.07
IL-17A is essential to the response against sub-lethal intranasal LVS infection
Gene_expression (infection) of LVS associated with sprains and strains and infection
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.00 Pain Relevance 0.07
Exogenous administration of IL-17A moderately delays time of death from lethal intranasal LVS infection
Gene_expression (infection) of LVS associated with sprains and strains, infection and death
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.60 Pain Relevance 0
The effect of sub-lethal intranasal infection with 0.1×LD50 LVS on activation and recruitment kinetics of pulmonary lymphocytes
Gene_expression (infection) of LVS in lymphocytes associated with sprains and strains and infection
11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.28 Pain Relevance 0
to the protection from LVS was clearly demonstrated in gamma interferon knockout (GKO) mice, which were highly susceptible to LVS infection via all routes [13], [18].
Gene_expression (protection) of LVS associated with targeted disruption, sprains and strains and infection
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.83 Pain Relevance 0
Exogenous administration of IL-23 moderately delays time of death from lethal intranasal LVS infection
Gene_expression (infection) of LVS associated with sprains and strains, infection and death
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.75 Pain Relevance 0.05
LVS infection resulted in a distinct increase in IL-17A+ producing cells both in CD4+ T and ??
Gene_expression (infection) of LVS associated with sprains and strains and infection
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.60 Pain Relevance 0.12
As in the case of NK cells, total T cell count in MdLN and lungs was essentially not effected by LVS infection (Figure 1D, inset).
Gene_expression (infection) of LVS in T cell associated with sprains and strains and infection
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.33 Pain Relevance 0
Since we demonstrate that the presence of IL-17A is important for protection from LVS (Figure 10), but the IL-17A-secreting ??
Gene_expression (protection) of LVS associated with sprains and strains
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.00 Pain Relevance 0.14
Cytokine production kinetics by pulmonary NK and T cells during LVS infection
Gene_expression (infection) of LVS in T cells associated with sprains and strains, infection and cytokine
17) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.98 Pain Relevance 0.09
In another very recently published report, the protective role of IL-17A against intradermal LVS infection was demonstrated with IL-17A knockout mice, while effects of exogenous cytokines promoting the IL-23/IL-17A axis were demonstrated in vitro in an intracellular LVS growth system [35].
Gene_expression (infection) of LVS associated with targeted disruption, sprains and strains, infection and cytokine
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.89 Pain Relevance 0.17
Female C57BL/6J mice were obtained from Jackson Labs in Bar Harbor, ME. 48 hours prior to Ft LVS challenge, mice were injected i.p. with either 100 ng of Ft LVS LPS or an equivalent volume of saline.
Gene_expression (challenge) of LVS in Bar associated with sprains and strains and francisella infection
19) Confidence 0.20 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 2.25 Pain Relevance 0.15
As shown in Figure 2B(ii), very few (<2 log10) LVS were present intracellularly at 3 h after infection, and intracellular bacteria remained at or below the level of detection throughout the 72 hr time course.
Gene_expression (present) of LVS associated with infection
20) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848594 Disease Relevance 0.60 Pain Relevance 0

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