INT251293

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, ERVW-1) extracellular region (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
brain 2
ITIH4 (Homo sapiens)
ERVW-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 49 100.00 Very High Very High Very High
Potency 4 56.92 Quite High
Central nervous system 7 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 45 71.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 44 50.00 Quite Low
Viral Meningitis 7 5.00 Very Low Very Low Very Low
Dementia 6 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Giant Cell Tumors 1 5.00 Very Low Very Low Very Low
Immunodeficiency 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Viral Infection 1 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, it seems that the gp120 subunit of the brain Env, and specifically the regions involved in conferring low CD4 dependence, are also involved in determining the increased fusogenicity and reduced sensitivity to fusion inhibitors, at least in these Env genetic backgrounds.
Regulation (involved) of gp120 Binding (subunit) of Env in brain associated with addiction
1) Confidence 0.27 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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