INT251295

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, ITIH4) signal transduction (CD4) extracellular region (ITIH4)
cell adhesion (CD4) enzyme binding (CD4) cytoplasm (ITIH4)
Anatomy Link Frequency
covering 2
CD4 (Homo sapiens)
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 3 83.68 Quite High
addiction 49 50.00 Quite Low
Central nervous system 7 29.20 Quite Low
anesthesia 1 8.88 Low Low
Potency 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunodeficiency 1 91.88 High High
Infection 45 76.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 44 75.92 Quite High
Syndrome 1 17.76 Low Low
Cognitive Disorder 1 14.80 Low Low
Dementia 6 11.36 Low Low
Viral Meningitis 7 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Giant Cell Tumors 1 5.00 Very Low Very Low Very Low
Viral Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction with CD4 triggers a rather large conformational change in gp120 that results in the formation and/or exposure of highly conserved regions previously folded into the core structure and/or sheltered by the variable loops and the glycans covering the outer domain of gp120 [2-9].
CD4 Binding (interaction) of in covering Regulation (change) of gp120
1) Confidence 0.11 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.24 Pain Relevance 0.11

General Comments

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