INT2513

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Context Info
Confidence 0.42
First Reported 1979
Last Reported 2010
Negated 4
Speculated 5
Reported most in Body
Documents 80
Total Number 85
Disease Relevance 4.29
Pain Relevance 6.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napa) vesicle-mediated transport (Napa)
Anatomy Link Frequency
vesicle 11
brain 3
hinge 2
synaptic vesicle 2
Parasympathetic 1
Napa (Mus musculus)
Pain Link Frequency Relevance Heat
antiepileptic Drug 7 100.00 Very High Very High Very High
opiate 6 99.92 Very High Very High Very High
Neurotransmitter 1116 99.80 Very High Very High Very High
Morphine 21 99.44 Very High Very High Very High
Dopamine 47 99.06 Very High Very High Very High
Kinase C 12 98.32 Very High Very High Very High
ischemia 28 93.76 High High
Potency 4 93.68 High High
carbamazepine 9 93.08 High High
Glutamate 64 92.12 High High
Disease Link Frequency Relevance Heat
Stress 17 98.76 Very High Very High Very High
Sialorrhea 9 96.12 Very High Very High Very High
Cv Unclassified Under Development 26 93.76 High High
Hypoglycemia 4 91.36 High High
Coma 15 88.12 High High
Ganglion Cysts 447 87.32 High High
Infection 2 83.96 Quite High
Attention Deficit Hyperactivity Disorder 30 82.84 Quite High
Affective Disorder 1 82.60 Quite High
Volume Depletion And Dehydration 1 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S5 A, available at http://www.jcb.org/cgi/content/full/jcb.200805150/DC1), suggesting that the activity of the WD-40 repeat domain to enhance the oligomerization of the SNARE complex is regulated by PKA-catalyzed phosphorylation.


SNARE Binding (oligomerization) of
1) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.15 Pain Relevance 0.08
Next, we compared the activity of tomosyn to enhance the oligomerization of the SNARE complex with that of complexin.
SNARE Binding (oligomerization) of
2) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Collectively, these results indicate that tomosyn has an ability to enhance oligomerization of the SNARE complex in vitro.


SNARE Binding (oligomerization) of
3) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Tomosyn-enhanced oligomerization of the SNARE complex in vitro
SNARE Binding (oligomerization) of
4) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
S5 shows the effect of the PKA-catalyzed phosphorylation of tomosyn on the oligomerization of the SNARE complex and binding of SNAP-25 to the WD-40 repeat domain of tomosyn.


SNARE Binding (oligomerization) of
5) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.05 Pain Relevance 0
Synaptic efficacy at mossy fiber synapses was enhanced in tomosyn-deficient mice, suggesting that tomosyn inhibits synaptic transmission in normal animals, most likely through regulation of the oligomerization of the SNARE complex.
SNARE Binding (oligomerization) of in synapses
6) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.13
However, this competing activity of the VLD does not explain the activity of tomosyn to enhance the oligomerization of the SNARE complex.
SNARE Binding (oligomerization) of
7) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Tomosyn enhanced the oligomerization of the SNARE complex even in the presence of 0.5 mM TCEP (Fig.
SNARE Binding (oligomerization) of
8) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Collectively, these results suggest that tomosyn achieves the oligomerization of the SNARE complex via both facilitation of the formation of the monomeric SNARE complex and enhancement of the oligomerization of the preassembled SNARE complex.


SNARE Binding (oligomerization) of
9) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
The activity of the WD-40 repeat domain to catalyze the oligomerization of the SNARE complex was repressed by the C-terminal VLD, suggesting that the catalytic activity of the WD-40 repeat domain competes with C-terminal VLD-based inhibition of SNARE complex formation.
SNARE Binding (oligomerization) of
10) Confidence 0.32 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.06
The fraction of PA cleared by the formation of NAPA in the corresponding acetylator group was 0.2 and 0.4.
NAPA Spec (cleared) Binding (formation) of
11) Confidence 0.31 Published 1979 Journal J Pharmacokinet Biopharm Section Abstract Doc Link 458558 Disease Relevance 0 Pain Relevance 0.09
MBP-VLD potently inhibited the formation of the ternary SNARE complex and the oligomerization of the SNARE complex in a dose-dependent manner (Fig. 6 B).
SNARE Binding (oligomerization) of
12) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Reduced formation of the oligomerized SNARE complex in the tomosyn-deficient brain
SNARE Binding (oligomerized) of in brain
13) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.12
These results indicate that the C-terminal VLD of tomosyn inhibits the formation of the ternary SNARE complex and thereby suppresses the oligomerization of the SNARE complex, which was basally induced or enhanced by the large N-terminal WD-40 repeat domain of tomosyn.
SNARE Binding (oligomerization) of
14) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Reduced formation of the oligomerized SNARE complex in the tomosyn-deficient brain
SNARE Binding (complex) of in brain
15) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.12
In addition, Rho-associated serine/threonine kinase activated by Rho small G protein phosphorylates syntaxin-1, thereby increasing the affinity of syntaxin-1 for tomosyn and the formation of a stable complex between the two, resulting in inhibition of the formation of the SNARE complex during neurite extension (Sakisaka et al., 2004).
SNARE Binding (complex) of in neurite
16) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.06 Pain Relevance 0
Regulation of N-terminal WD-40 repeat domain–induced oligomerization of the SNARE complex by the C-terminal VLD
SNARE Binding (complex) of
17) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
However, it remains unknown whether the WD-40 repeat domain of Sro7 catalyzes the oligomerization of the SNARE complex as tomosyn does.
SNARE Binding (oligomerization) of
18) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.07 Pain Relevance 0
These results also suggest that although tomosyn negatively regulates formation of the ternary SNARE complex via the C-terminal VLD and positively regulates the oligomerization of the SNARE complex via the large N-terminal WD-40 repeat domain, the actions of the C-terminal VLD and the large N-terminal WD-40 repeat domain are mutually exclusive.
SNARE Binding (oligomerization) of
19) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
We examined the effect of the VLD on large N-terminal WD-40 repeat domain–induced oligomerization of the SNARE complex.
SNARE Spec (examined) Binding (oligomerization) of
20) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0

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