INT25130

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 5.07
Pain Relevance 6.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
mesentery 4
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cOX1 7 100.00 Very High Very High Very High
cINOD 35 99.80 Very High Very High Very High
Inflammation 14 99.80 Very High Very High Very High
Opioid 10 99.80 Very High Very High Very High
tolerance 9 99.52 Very High Very High Very High
adenocard 1 99.36 Very High Very High Very High
COX2 6 99.24 Very High Very High Very High
acular 1 99.24 Very High Very High Very High
Endocannabinoid 3 98.64 Very High Very High Very High
Morphine 2 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 31 99.80 Very High Very High Very High
Disease 5 99.38 Very High Very High Very High
Bronchospasm 1 98.24 Very High Very High Very High
Stroke 2 97.44 Very High Very High Very High
Myocardial Infarction 1 97.00 Very High Very High Very High
Cv General 3 Under Development 1 95.52 Very High Very High Very High
Pressure And Volume Under Development 1 93.12 High High
Urticaria 3 92.40 High High
Ulcers 3 90.96 High High
Pain 5 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that three potent inhibitors of PGH synthase can, paradoxically, increase prostaglandin production at low concentrations.
Positive_regulation (increase) of Negative_regulation (inhibitors) of PGH synthase
1) Confidence 0.50 Published 1989 Journal Prostaglandins Section Abstract Doc Link 2500679 Disease Relevance 0.07 Pain Relevance 0.07
It is widely accepted that the classical constant-temperature hot-plate test is insensitive to cyclooxygenase inhibitors.
Positive_regulation (insensitive) of Negative_regulation (inhibitors) of cyclooxygenase
2) Confidence 0.50 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15761625 Disease Relevance 0.31 Pain Relevance 0.23
Specific blockade of cyclooxygenase-1 or cyclooxygenase-2 does not induce any inflammatory event in the rat mesentery and the inflammatory response observed with non-selective NSAIDs seems to be due to the inhibition of both isoenzymes.
Neg (not) Positive_regulation (induce) of Negative_regulation (blockade) of cyclooxygenase in mesentery associated with inflammatory response, inflammation and cinod
3) Confidence 0.48 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11959090 Disease Relevance 0.41 Pain Relevance 0.31
Specific blockade of cyclooxygenase-1 or cyclooxygenase-2 does not induce any inflammatory event in the rat mesentery and the inflammatory response observed with non-selective NSAIDs seems to be due to the inhibition of both isoenzymes.
Neg (not) Positive_regulation (induce) of Negative_regulation (blockade) of cyclooxygenase-1 in mesentery associated with inflammatory response, inflammation and cinod
4) Confidence 0.48 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11959090 Disease Relevance 0.41 Pain Relevance 0.31
Nonsteroidal anti-inflammatory drug gastropathy is usually antral/prepyloric disease, and research indicates it is mediated through blockade of cyclooxygenase with reduction in cytoprotective gastric prostaglandins.
Positive_regulation (mediated) of Negative_regulation (blockade) of cyclooxygenase associated with inflammation, cinod and disease
5) Confidence 0.46 Published 1987 Journal Arch. Intern. Med. Section Abstract Doc Link 3318750 Disease Relevance 1.11 Pain Relevance 0.43
NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.
Positive_regulation (requirement) of Negative_regulation (inhibition) of cyclooxygenase associated with cinod and cox1
6) Confidence 0.22 Published 2000 Journal Gastroenterology Section Title Doc Link 10982765 Disease Relevance 0.10 Pain Relevance 0.63
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce an inhibition of cyclooxygenase (COX), an enzyme that makes prostaglandins.
Positive_regulation (induce) of Negative_regulation (inhibition) of cyclooxygenase associated with inflammation and cinod
7) Confidence 0.11 Published 1999 Journal Kidney Int. Section Abstract Doc Link 10571785 Disease Relevance 0.34 Pain Relevance 0.35
Synthesis, biological evaluation, and molecular modeling of oleuropein and its semisynthetic derivatives as cyclooxygenase inhibitors.
Positive_regulation (derivatives) of Negative_regulation (inhibitors) of cyclooxygenase
8) Confidence 0.04 Published 2009 Journal J. Agric. Food Chem. Section Title Doc Link 19908866 Disease Relevance 0.08 Pain Relevance 0.08
In such patients, cross-reactivity to all NSAIDs seems to occur suggesting a mechanism dependent on cyclooxygenase inhibition.
Positive_regulation (dependent) of Negative_regulation (inhibition) of cyclooxygenase associated with cinod
9) Confidence 0.04 Published 2000 Journal Ann. Allergy Asthma Immunol. Section Abstract Doc Link 10982225 Disease Relevance 0.45 Pain Relevance 0.35
More recent data on the effect of combining the two compounds leading to an irreversible blockade of cyclooxygenase as well as the adenosine diphosphate receptor showed increased protection from cardiac events in patients with unstable angina and no significant protection from stroke.
Positive_regulation (leading) of Negative_regulation (blockade) of cyclooxygenase associated with angina, adenocard and stroke
10) Confidence 0.02 Published 2001 Journal Am J Ther Section Abstract Doc Link 11704783 Disease Relevance 0.46 Pain Relevance 0.19
CONCLUSION: Piroxicam's oral clearance was impaired and its inhibitory effect on cyclooxygenase 1 activity was increased in CYP2C9*1/*2 or CYP2C9*1/*3 individuals, as compared with CYP2C 9*1 homozygous individuals.


Positive_regulation (increased) of Negative_regulation (effect) of cyclooxygenase 1
11) Confidence 0.02 Published 2005 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16198655 Disease Relevance 0 Pain Relevance 0
It has been suggested that the mechanisms of action of NSAIDs could be due to inhibition of cyclooxygenase (COX) and also to an increase in endocannabinoid concentrations.
Positive_regulation (due) of Negative_regulation (inhibition) of cyclooxygenase associated with endocannabinoid and cinod
12) Confidence 0.02 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17027744 Disease Relevance 0.25 Pain Relevance 0.70
The mechanism of action of these drugs is attributed to the inhibition of cyclooxygenase (COX), and, consequently, the conversion of arachidonic acid into prostaglandins.
Positive_regulation (attributed) of Negative_regulation (inhibition) of cyclooxygenase
13) Confidence 0.01 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11728379 Disease Relevance 0.71 Pain Relevance 0.63
Recently, our and others' studies also found that cyclooxygenase (COX) inhibitors could attenuate the opioid tolerance without enhancing morphine's antinociceptive effect.
Positive_regulation (attenuate) of Negative_regulation (inhibitors) of cyclooxygenase associated with tolerance, antinociceptive, opioid and morphine
14) Confidence 0.01 Published 2000 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 11125691 Disease Relevance 0.38 Pain Relevance 2.00

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