INT251303

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 3.87
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HR) DNA binding (HR)
Anatomy Link Frequency
spleen 1
eosinophils 1
HR (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 40 99.44 Very High Very High Very High
agonist 1 97.20 Very High Very High Very High
addiction 196 81.92 Quite High
Inflammation 5 76.64 Quite High
Potency 16 74.00 Quite High
Dismenorea 11 56.68 Quite High
endometriosis 1 54.12 Quite High
depression 10 17.60 Low Low
Central nervous system 28 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 121 99.38 Very High Very High Very High
Chronic Disease 70 99.20 Very High Very High Very High
Endometriosis (extended) 259 96.48 Very High Very High Very High
Anxiety Disorder 10 89.28 High High
Hot Flashes 20 88.04 High High
Clinical Trials And Case Reports 20 85.04 High High
Cancer 37 84.52 Quite High
Hookworm Infection 35 84.08 Quite High
Nicotine Addiction 50 82.96 Quite High
Rhinitis 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been reported that moderate alcohol consumption has a positive association with HR-QoL in middle aged women [31]; therefore, we combined non-drinkers and occasional drinkers in a single group and presented the data for moderate alcohol consumption only.
HR-QoL Binding (association) of associated with alcohol
1) Confidence 0.47 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0.70 Pain Relevance 0.19
Factors such as older age, lack of partner and/or children, unfavorable socioeconomic conditions, low social support, presence of chronic diseases, obesity, and unhealthy lifestyles are associated with low HR-QoL as well [9-11].
HR-QoL Binding (associated) of associated with obesity and chronic disease
2) Confidence 0.41 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0.55 Pain Relevance 0
We estimated a sample size of 400 women to evaluate the possible association between HR-QoL and quality of care.
HR-QoL Binding (association) of
3) Confidence 0.41 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0.41 Pain Relevance 0
Because most of the women in the sample do not need to receive either oral or vaginal HT, the results reflect the proper "no indication" more, so the association between HR-QoL and quality of care in the treatment component was probably overestimated.
HR-QoL Binding (association) of
4) Confidence 0.41 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0.06 Pain Relevance 0
There is a positive association between the quality of treatment and HR-QoL, which can encourage the development of interventions aimed at improving the performance of health services.
HR-QoL Binding (association) of
5) Confidence 0.41 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0 Pain Relevance 0
Evaluation of the quality of care and its association with HR-QoL through a cross-sectional study conducted in two FMC located in Mexico City that included 410 climacteric stage women.
HR-QoL Binding (association) of
6) Confidence 0.35 Published 2010 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC2844365 Disease Relevance 0 Pain Relevance 0
The association between global HR-QoL score and the percentage of recommended care received for each component of care (health promotion, screening and treatment), as well as for each of the covariates was evaluated through the Spearman correlation test.
HR-QoL Binding (association) of
7) Confidence 0.31 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0.17 Pain Relevance 0
There is a positive association between the quality of the treatment component and HR-QoL; this would encourage interventions to improve quality of care for climacteric stage women.



HR-QoL Binding (association) of
8) Confidence 0.30 Published 2010 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC2844365 Disease Relevance 0 Pain Relevance 0
Assessment of the quality of care and of its association with HR-QoL in climacteric stage women.
HR-QoL Binding (association) of
9) Confidence 0.30 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0.21 Pain Relevance 0
The association between HR-QoL and the health promotion and screening components was not statistically significant.


HR-QoL Binding (association) of
10) Confidence 0.30 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2844365 Disease Relevance 0 Pain Relevance 0
This effect turned out to depend on the hrLH binding to its specific receptor and on the following activation of the cAMP/PKA signaling pathway.
hrLH Binding (binding) of
11) Confidence 0.01 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 1.10 Pain Relevance 0.08
On the other hand, the release of histamine by activated eosinophils may downregulate DC differentiation through induction of IL-10 production by lymphocytes and mDCs, after interaction with histamine receptor type 2 (HR2) on these cells [53].
HR2 Binding (interaction) of in eosinophils
12) Confidence 0.00 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.66 Pain Relevance 0.09
In this assay, a biotinylated, HR1-derived peptide (N40) was synthesized and immobilized onto the surface of a streptavidin-coated chip to evaluate binding of the HR2-derived T-1249 and T-1249-BR using a BiacoreĀ® 3000 optical biosensor.
HR2 Binding (binding) of
13) Confidence 0.00 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0 Pain Relevance 0.07
In summary, the amino acid changes found in the HR2 region of gp41 in brain-derived Env from H0002GH did not seem to affect the interaction between HR2- and HR1-derived peptides in biosensor experiments, and did not seem to contribute to the increased fusogenicity or to the reduced sensitivity to fusion inhibitors, as compared to the spleen-derived Env.
HR2 Binding (interaction) of in spleen
14) Confidence 0.00 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0 Pain Relevance 0.07
Although the high fusogenicity of the BS and Bv1v3 but not the SB chimeras seems to indicate that these changes in gp41 do not determine the fusogenicity observed, it would still be possible that they play a role in the reduced sensitivity to fusion inhibitors, e.g., by promoting an improved interaction between HR1 and HR2 that might lead to a more efficient fusion process and/or reduced sensitivity to inhibitors.
HR2 Spec (might) Binding (interaction) of
15) Confidence 0.00 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0 Pain Relevance 0.10
Although the high fusogenicity of the BS and Bv1v3 but not the SB chimeras seems to indicate that these changes in gp41 do not determine the fusogenicity observed, it would still be possible that they play a role in the reduced sensitivity to fusion inhibitors, e.g., by promoting an improved interaction between HR1 and HR2 that might lead to a more efficient fusion process and/or reduced sensitivity to inhibitors.
HR1 Spec (might) Binding (interaction) of
16) Confidence 0.00 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0 Pain Relevance 0.10

General Comments

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