INT251323

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.26
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Limk1) nucleus (Limk1) kinase activity (Limk1)
cytoplasm (Limk1)
Anatomy Link Frequency
eyes 2
Limk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 99 98.20 Very High Very High Very High
fibrosis 36 96.52 Very High Very High Very High
Inflammatory response 27 90.48 High High
ketamine 3 36.04 Quite Low
anesthesia 3 34.28 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular & Orbital Inflammation 39 98.20 Very High Very High Very High
Fibrosis 42 96.52 Very High Very High Very High
INFLAMMATION 87 90.12 High High
Adhesions 27 83.04 Quite High
Dislocations 3 65.52 Quite High
Injury 42 58.84 Quite High
Keloid Scars 24 37.76 Quite Low
Glaucoma 12 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Cataract 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A direct application of siRNA into eyes to downregulate LIMK1 expression may provide a novel therapy for suppression and prevention of ocular inflammation and fibrosis.



Negative_regulation (downregulate) of Gene_expression (expression) of LIMK1 in eyes associated with fibrosis, inflammation and ocular & orbital inflammation
1) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.90 Pain Relevance 0.35
The fibronectin deposition was significantly diminished in cultures 48 (data not shown) and 72 h (Figure 1D,E) after transfection with both 50 nM and 100 nM LIMK1 siRNA.
Negative_regulation (diminished) of Gene_expression (transfection) of LIMK1
2) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.05 Pain Relevance 0.03
LIMK1 siRNA inhibits fibronectin assembly and fibronectin secretion
Negative_regulation (inhibits) of Gene_expression (assembly) of LIMK1
3) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.30 Pain Relevance 0.12

General Comments

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