INT251328

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) cell adhesion (Fn1) proteinaceous extracellular matrix (Fn1)
extracellular matrix organization (Fn1)
Anatomy Link Frequency
fibroblasts 2
Fn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 132 89.20 High High
Inflammatory response 36 81.60 Quite High
fibrosis 48 66.12 Quite High
ketamine 4 35.56 Quite Low
anesthesia 4 33.80 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 36 97.72 Very High Very High Very High
Ocular & Orbital Inflammation 52 89.76 High High
Injury 56 84.96 Quite High
INFLAMMATION 116 84.40 Quite High
Fibrosis 56 66.12 Quite High
Dislocations 4 65.04 Quite High
Keloid Scars 32 37.28 Quite Low
Stress 12 9.04 Low Low
Glaucoma 16 5.00 Very Low Very Low Very Low
Cataract 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the immunofluorescence data, treatment with 50 nM or 100 nM LIMK1 siRNA resulted in decreased fibronectin secretion into the culture; the reduction, up to 80%, was dose- dependent.


Negative_regulation (decreased) of Localization (secretion) of fibronectin
1) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.23 Pain Relevance 0
To determine whether the effect of LIMK1 siRNA on fibronectin fibrillogenesis was due to a decreased fibronectin secretion, we analyzed the amount of secreted fibronectin by western blotting (Figure 1F).
Spec (whether) Negative_regulation (decreased) of Localization (secretion) of fibronectin
2) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.11 Pain Relevance 0
LIMK1 siRNA inhibits fibronectin assembly and fibronectin secretion
Negative_regulation (inhibits) of Localization (secretion) of fibronectin
3) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.30 Pain Relevance 0.12
Downregulation of LIMK1 in cultured corneal fibroblasts impaired fibronectin secretion and assembly, diminished actin polymerization and focal adhesion formation, and retarded cell migration.
Negative_regulation (impaired) of Localization (secretion) of fibronectin in fibroblasts associated with adhesions
4) Confidence 0.07 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.92 Pain Relevance 0.33

General Comments

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