INT251332

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 20
Disease Relevance 16.43
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Limk1) nucleus (Limk1) kinase activity (Limk1)
cytoplasm (Limk1)
Anatomy Link Frequency
fibroblasts 4
eyes 3
leukocyte 1
Limk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 660 99.68 Very High Very High Very High
Inflammatory response 180 99.40 Very High Very High Very High
fibrosis 240 98.56 Very High Very High Very High
ketamine 20 32.88 Quite Low
anesthesia 20 31.12 Quite Low
cytokine 20 26.00 Quite Low
Disease Link Frequency Relevance Heat
Ocular & Orbital Inflammation 260 99.68 Very High Very High Very High
Adhesions 180 99.40 Very High Very High Very High
Injury 280 99.20 Very High Very High Very High
Infection 20 99.20 Very High Very High Very High
INFLAMMATION 580 99.04 Very High Very High Very High
Age-related Macular Degeneration 20 98.60 Very High Very High Very High
Fibrosis 280 98.56 Very High Very High Very High
Stress 60 96.12 Very High Very High Very High
Keloid Scars 160 93.20 High High
Glaucoma 80 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous LIMK1 was downregulated in human corneal fibroblasts using a LIMK1-specific siRNA at both 48 and 72 h post-transfection time points.
Negative_regulation (downregulated) of LIMK1 in fibroblasts
1) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.29 Pain Relevance 0.11
As actin cytoskeleton dynamics and cell adhesion to the ECM are crucially involved in cell migration [27], we investigated whether actin dynamics and focal adhesion formation were affected upon downregulation of LIMK1.
Spec (whether) Negative_regulation (downregulation) of LIMK1 associated with adhesions
2) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.92 Pain Relevance 0.09
Therefore downregulation of LIMK1 might be an effective strategy in suppression and prevention of ocular inflammation and fibrosis.
Negative_regulation (downregulation) of LIMK1 associated with fibrosis, inflammation and ocular & orbital inflammation
3) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 1.41 Pain Relevance 0.35
-dependent cell migration may be explained by the impairment of effective actin cytoskeleton dynamics since LIMK1 downregulation resulted in reduced actin polymerization, fibronectin deposition, and focal adhesion formation (Figure 3 and [1]).
Negative_regulation (downregulation) of LIMK1 associated with adhesions
4) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.31 Pain Relevance 0
Downregulation of LIMK1 in leukocytes was also observed to decrease leukocyte chemotaxis in Transwell assay, presumably via impairment of actin polymerization (unpublished data).
Negative_regulation (Downregulation) of LIMK1 in leukocyte
5) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.84 Pain Relevance 0.33
The influence of LIMK1 downregulation on TGF-?
Negative_regulation (downregulation) of LIMK1
6) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.36 Pain Relevance 0
A scratch wound closure assay was used to test whether downregulation of LIMK1 would affect corneal fibroblasts motility.
Spec (whether) Negative_regulation (downregulation) of LIMK1 in fibroblasts associated with injury
7) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.40 Pain Relevance 0
Also, downregulation of LIMK1 via genetic deletion or direct application of LIMK1-targeted siRNA in the eyes of a mouse model markedly decreased ocular inflammatory response.
Negative_regulation (downregulation) of LIMK1 in eyes associated with inflammatory response
8) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 1.62 Pain Relevance 0.41
The effects of LIMK1 downregulation on actin cytoskeleton organization and focal adhesion formation were studied.
Negative_regulation (downregulation) of LIMK1 associated with adhesions
9) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.61 Pain Relevance 0.21
In the mouse model of ocular inflammation, both genetic deletion and downregulation of LIMK1 by siRNA significantly reduced inflammatory response.


Negative_regulation (downregulation) of LIMK1 associated with inflammatory response, inflammation and ocular & orbital inflammation
10) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.88 Pain Relevance 0.32
Downregulation of LIMK1 was efficacious to decrease the ocular inflammation.
Negative_regulation (Downregulation) of LIMK1 associated with inflammation and ocular & orbital inflammation
11) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.87 Pain Relevance 0.32
Downregulation of LIMK1 in cultured corneal fibroblasts impaired fibronectin secretion and assembly, diminished actin polymerization and focal adhesion formation, and retarded cell migration.
Negative_regulation (Downregulation) of LIMK1 in fibroblasts associated with adhesions
12) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.91 Pain Relevance 0.33
The purpose of this study was to determine if downregulation of LIM kinase 1 (LIMK1) by genetic deletion or direct application of LIMK1-targeted siRNA could suppress TGF-?
Negative_regulation (downregulation) of LIM kinase 1
13) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.48 Pain Relevance 0.18
We showed here that downregulation of LIMK1 in human corneal fibroblasts led to a significant decrease in fibronectin deposition.
Negative_regulation (downregulation) of LIMK1 in fibroblasts
14) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 1.29 Pain Relevance 0.39
We demonstrate that downregulation of LIMK1 via genetic deletion or direct application of mouse LIMK1-targeted siRNA in the eyes of a mouse model significantly decreased ocular inflammatory response.
Negative_regulation (downregulation) of LIMK1 in eyes associated with inflammatory response
15) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.56 Pain Relevance 0.21
The purpose of this study was to determine if downregulation of LIM kinase 1 (LIMK1) by genetic deletion or direct application of LIMK1-targeted siRNA could suppress TGF-?
Negative_regulation (downregulation) of LIMK1
16) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.48 Pain Relevance 0.18
Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis

Purpose

Negative_regulation (Downregulation) of LIM kinase 1 associated with fibrosis, inflammation and ocular & orbital inflammation
17) Confidence 0.43 Published 2008 Journal Molecular Vision Section Title Doc Link PMC2576479 Disease Relevance 0.65 Pain Relevance 0.22
Downregulation of LIMK1 via genetic deletion or siRNA reduces ocular inflammation in a mouse model
Negative_regulation (Downregulation) of LIMK1 associated with inflammation and ocular & orbital inflammation
18) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 1.20 Pain Relevance 0.26
signaling, and that downregulation of LIMK1 might be an effective strategy to suppress ocular inflammation and fibrosis.
Negative_regulation (downregulation) of LIMK1 associated with fibrosis, inflammation and ocular & orbital inflammation
19) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 1.37 Pain Relevance 0.41
Moreover, downregulation of LIMK1 in a mouse model via both genetic deletion and direct application of LIMK1-targeted siRNA in the eyes markedly reduced ocular inflammation.


Negative_regulation (downregulation) of LIMK1 in eyes associated with inflammation and ocular & orbital inflammation
20) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.97 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox