INT251333

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Limk1) nucleus (Limk1) kinase activity (Limk1)
cytoplasm (Limk1)
Limk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 66 50.00 Quite Low
fibrosis 24 21.84 Low Low
Inflammatory response 18 12.12 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular & Orbital Inflammation 26 50.00 Quite Low
Adhesions 18 48.40 Quite Low
Injury 28 46.08 Quite Low
INFLAMMATION 58 38.96 Quite Low
Stress 6 32.28 Quite Low
Fibrosis 28 21.84 Low Low
Dislocations 2 19.60 Low Low
Keloid Scars 16 5.00 Very Low Very Low Very Low
Glaucoma 8 5.00 Very Low Very Low Very Low
Cataract 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the effect of LIMK1 siRNA on fibronectin fibrillogenesis was due to a decreased fibronectin secretion, we analyzed the amount of secreted fibronectin by western blotting (Figure 1F).
Spec (whether) Regulation (effect) of LIMK1
1) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0 Pain Relevance 0
The specificity of the LIMK1 siRNA was verified or the siRNA study was validated by using 1) mismatch controls, where mutation of only several nucleotides completely abolished the silencing effect; and 2) several siRNAs targeted against different regions on LIMK1 mRNA, which showed similar silencing effects.
Regulation (targeted) of LIMK1
2) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0 Pain Relevance 0

General Comments

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