INT25134

Context Info Confidence 0.49 First Reported 1989 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 3.38 Pain Relevance 0.66

cell adhesion (CD9) plasma membrane (CD9)

CD9 (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 65 99.92 Paracetamol 1 85.36 algil 1 84.64 headache 1 81.28 methadone 2 75.00 drug abuse 1 67.00 Inflammation 8 5.00 chemokine 5 5.00 Central nervous system 4 5.00 cytokine 4 5.00

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 15 99.98 Multiple Sclerosis 69 99.92 Sarcoma 7 95.44 Pressure Volume 2 Under Development 2 88.96 Arthralgia 1 87.40 Fatigue 1 86.36 Aids-related Complex 2 86.08 Headache 1 81.28 Fever 2 80.36 Cancer 4 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, levels of circulating beta 2-microglobulin, SCD8, SIL-2R, and HIV p24 antigen were significantly elevated in the HIV-seropositive group compared with the HIV-seronegative group.

Positive_regulation (elevated) of p24 associated with acquired immune deficiency syndrome or hiv infection

1) Confidence 0.49 Published 1989 Journal AIDS Section Abstract Doc Link 2500957 Disease Relevance 1.20 Pain Relevance 0.18

Serum human immunodeficiency virus (HIV) p24 antigen levels increased greater than 50% in three patients.

Positive_regulation (increased) of p24 associated with acquired immune deficiency syndrome or hiv infection

2) Confidence 0.49 Published 1989 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 2918461 Disease Relevance 1.72 Pain Relevance 0.25

For each of these genes, some samples were negative for expression by RT-qPCR (control sample 8921A for SERPINB9 and CD9, MS sample 8922A for CD83), and the influence of the negative values is not fully accounted for when pooling the samples prior to analysis by the ??

Positive_regulation (8921A) of CD9 associated with multiple sclerosis

3) Confidence 0.13 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.46 Pain Relevance 0.23

General Comments

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