INT251364

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.02
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) Golgi apparatus (Cdh1) plasma membrane (Cdh1)
cytoplasm (Cdh1)
Anatomy Link Frequency
lactotrophs 2
adenohypophysis 2
Cdh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 79.44 Quite High
anesthesia 9 32.64 Quite Low
isoflurane 2 13.24 Low Low
alcohol 2 5.84 Low Low
Inflammation 18 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 54 98.04 Very High Very High Very High
Ureteral Obstruction 50 93.84 High High
Stress 24 82.00 Quite High
Fibrosis 40 80.00 Quite High
Shock 4 32.60 Quite Low
Exsanguination 2 30.64 Quite Low
Weight Loss 2 20.64 Low Low
Urinary Tract Infection 2 20.44 Low Low
Death 2 18.04 Low Low
Adhesions 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We are inclined to conclude that this result is linked to the observation that E-cadherin expression is lost in hormone-producing cells at the onset of hormone production in the developing adenohypophysis [9].



Negative_regulation (lost) of Gene_expression (expression) of E-cadherin in adenohypophysis
1) Confidence 0.32 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0 Pain Relevance 0
It is unlikely that E-cadherin expression inhibited translation, which leaves two possibilities.
Negative_regulation (inhibited) of Gene_expression (expression) of E-cadherin
2) Confidence 0.32 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.31 Pain Relevance 0
The present study has shown that forced E-cadherin expression in lactotrophs of adult rats significantly reduced prolactin content.
Negative_regulation (reduced) of Gene_expression (expression) of E-cadherin in lactotrophs
3) Confidence 0.32 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0 Pain Relevance 0
Also, it was possible to clearly observe the specific coexpression of E-cadherin and N-cadherin during the formation of certain organs, and the present study enabled us to morphologically clarify cadherin switching.
Negative_regulation (observe) of Gene_expression (coexpression) of E-cadherin
4) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.03
In the present study, it was possible to visualize the expression patterns of E-cadherin and N-cadherin during early fetal development.
Spec (possible) Negative_regulation (visualize) of Gene_expression (expression) of E-cadherin
5) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.04
Double staining of E-cadherin/?
Negative_regulation (Double) of Gene_expression (staining) of E-cadherin
6) Confidence 0.09 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0 Pain Relevance 0
Treatment with juglone preserved distal E-cadherin expression and decreased interstitial ?
Negative_regulation (preserved) of Gene_expression (expression) of E-cadherin
7) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.72 Pain Relevance 0

General Comments

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