INT251387

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.46
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular amino acid metabolic process (Sds)
cytoplasm (Sds)
Anatomy Link Frequency
neuronal 1
Sds (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 77 97.64 Very High Very High Very High
GABAergic 21 94.36 High High
antagonist 7 85.28 High High
Neurotransmitter 28 83.56 Quite High
Glutamate 63 79.04 Quite High
depression 7 52.24 Quite High
adenocard 112 38.52 Quite Low
Pyramidal cell 70 17.88 Low Low
tetrodotoxin 7 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 100.00 Very High Very High Very High
Neurological Disease 7 76.84 Quite High
Epilepsy 7 52.80 Quite High
Depression 7 52.24 Quite High
Anxiety Disorder 7 51.76 Quite High
Cognitive Disorder 14 50.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the auxiliary factor binding to SDs of
GABAB1a at the cell surface remains to be identified.
SDs Binding (binding) of
1) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.25
This suggests that the SDs of GABAB1a bind to protein(s) that
localize heteroreceptors at glutamatergic terminals. 
SDs Binding (bind) of
2) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.08 Pain Relevance 0
We show that the two SDs, when expressed as a soluble protein,
bind to neuronal membranes with low nanomolar affinity. 
SDs Binding (bind) of in neuronal
3) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0.08 Pain Relevance 0.16
We did not observe that RSDP co-immunoprecipitates
with GABAB1a after co-expression in HEK293 cells, suggesting that
SDs do not recruit heteroreceptors through homophilic interactions either
(data not shown). 
SDs Binding (interactions) of
4) Confidence 0.21 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.25
Of importance
for drug discovery, our data also demonstrate that it is possible to
selectively impair GABAB heteroreceptors by targeting their
SDs.



SDs Binding (targeting) of
5) Confidence 0.21 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.06
Most likely, the extracellular binding partner of the SDs acts as a diffusion
trap that keeps heteroreceptors and elements of the release machinery in close
proximity. 
SDs Binding (partner) of
6) Confidence 0.21 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.31
SDs, also known as
complement control modules or short consensus repeats, mediate protein
interactions in adhesion molecules and in G-protein-coupled receptors binding
to peptide hormones (20,
21). 
SDs Binding (binding) of associated with adhesions
7) Confidence 0.21 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.31 Pain Relevance 0.09

General Comments

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