INT251388

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gabbr1) plasma membrane (Gabbr1) transcription factor binding (Gabbr1)
cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Anatomy Link Frequency
extracellular matrix 2
Fbln2 (Mus musculus)
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 27 97.08 Very High Very High Very High
Neurotransmitter 12 92.56 High High
gABA 33 84.16 Quite High
adenocard 48 66.60 Quite High
antagonist 3 60.16 Quite High
Pyramidal cell 30 49.96 Quite Low
depression 3 21.36 Low Low
GABAergic 9 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 73.76 Quite High
Epilepsy 3 21.92 Low Low
Depression 3 21.36 Low Low
Anxiety Disorder 3 20.88 Low Low
Cognitive Disorder 6 20.04 Low Low
Neurological Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiments, the extracellular matrix protein fibulin-2, which binds to
the first SD of GABAB1a
(19), was without effect on
heteroreceptor function. 
fibulin-2 Binding (binds) of GABAB1a in extracellular matrix
1) Confidence 0.08 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.16
A protein binding to the
first SD of GABAB1a is the extracellular matrix protein fibulin-2,
but whether it mediates GABAB receptor localization is unknown
(19).
fibulin-2 Binding (binding) of GABAB1a in extracellular matrix
2) Confidence 0.08 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.07 Pain Relevance 0
Incubation
of slices with 40 nm recombinant fibulin-2, a known binding partner
of GABAB1a (19),
did not interfere with the baclofen-induced inhibition of evoked glutamate
release (supplemental Fig. 3, A and B). 
fibulin-2 Binding (partner) of GABAB1a associated with glutamate
3) Confidence 0.06 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.14

General Comments

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