INT251390

Context Info Confidence 0.28 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.52 Pain Relevance 0.26

signal transduction (Gnat3) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 11 97.76 headache 7 90.96 tolerance 14 5.00 transdermal 8 5.00 addiction 5 5.00 cINOD 2 5.00 Somatostatin 2 5.00 corticosteroid 1 5.00 Inflammation 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Pressure Volume 2 Under Development 8 92.24 Headache 7 90.96 Pancreatitis 70 50.00 Vomiting 4 42.32 Exanthema 2 30.56 Increased Venous Pressure Under Development 2 5.00 Muscular Spasm 1 5.00 Disease 1 5.00 Injury 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Adverse effect of using GTN

Regulation (effect) of Gene_expression (using) of GTN

1) Confidence 0.28 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2921391 Disease Relevance 0.52 Pain Relevance 0.26

The model correctly predicts that the fraction of ALDH2 that is irreversibly inactivated by GTN in the absence of DTT will depend on the GTN concentration but not on the concentrations of DTT and acetaldehyde applied to reactivate the enzyme.

Neg (not) Regulation (depend) of Gene_expression (concentration) of GTN

2) Confidence 0.19 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

General Comments

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