INT251420

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.28

cytoplasm (Aldh3a1, Gnat3) cytosol (Aldh3a1) signal transduction (Gnat3) oxidoreductase activity (Aldh3a1) aging (Aldh3a1) endoplasmic reticulum (Aldh3a1)

Aldh3a1 (Rattus norvegicus) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 14 96.56 addiction 5 88.00 Angina 1 7.72

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 77.96 Cv General 3 Under Development 1 7.72 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One attractive characteristic of the proposal that mitochondrial ALDH is responsible for GTN biotransformation is the fact that it can accommodate one of the more common explanations for nitrate tolerance in a slightly modified version.

mitochondrial ALDH Regulation (responsible) of Gene_expression (biotransformation) of GTN associated with tolerance

1) Confidence 0.09 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.08 Pain Relevance 0.28

General Comments

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