INT251427

Context Info Confidence 0.26 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.05

mitochondrion (Aldh2) signal transduction (Gnat3) oxidoreductase activity (Aldh2) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Gnat3 (Mus musculus) Aldh2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tolerance 14 98.20 addiction 5 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 5.00 Stress 1 5.00 Cv General 3 Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance.

GTN Positive_regulation (inactivation) of ALDH2 associated with tolerance

1) Confidence 0.26 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.05

General Comments

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