INT251428

Context Info Confidence 0.19 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

signal transduction (Gnat3) mitochondrion (Aldh2) oxidoreductase activity (Aldh2) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Aldh2 (Rattus norvegicus) Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 28 5.00 addiction 10 5.00 Angina 2 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 4 5.00 Stress 2 5.00 Cv General 3 Under Development 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the presence of NAD(H) is no prerequisite for the reduction of GTN by ALDH2, it is conceivable that the enzyme uses NADH as a facultative electron donor.

ALDH2 Negative_regulation (reduction) of GTN

1) Confidence 0.19 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

FIGURE 7.Effect of preincubation of ALDH2 with GTN on the ALDH2-catalyzed reduction of GTN.

ALDH2-catalyzed Negative_regulation (reduction) of GTN

2) Confidence 0.17 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

General Comments

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