INT251430

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.48 Pain Relevance 0.42

cytoplasm (Gnat3, Gucy1b2) cytosol (Gucy1b2) signal transduction (Gnat3) ion binding (Gucy1b2) GTPase activity (Gnat3) signal transducer activity (Gnat3)

Gnat3 (Mus musculus) Gucy1b2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Angina 4 98.64 tolerance 56 94.68 addiction 20 73.32

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 8 100.00 Cv General 3 Under Development 4 98.64 Stress 4 45.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GTN activates sGC non-enzymatically in the presence of cysteine and a few structurally related thiols (4–6) via NO release (7).

GTN Positive_regulation (activates) of sGC

1) Confidence 0.04 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.18 Pain Relevance 0.13

Interestingly, activation of sGC by GTN has been accomplished in the presence of purified mitochondrial ALDH2, suggesting that the ALDH2-catalyzed decomposition of GTN yields NO (12); the physiological relevance of this observation is not clear yet.

GTN Positive_regulation (activation) of sGC

2) Confidence 0.04 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.10 Pain Relevance 0.11

GTN can stimulate sGC in the presence of purified ALDH2, and this stimulation is mediated by NO even though the proposed mechanism for ALDH-supported decomposition of GTN predicts nitrite as the only product (12).

GTN Positive_regulation (stimulate) of sGC

3) Confidence 0.03 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.03

GTN is thought to cause vasodilatation mainly by activation of soluble guanylate cyclase (sGC), which is stimulated by the binding of NO to a regulatory heme group.

GTN Positive_regulation (activation) of sGC associated with increased venous pressure under development

4) Confidence 0.02 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.20 Pain Relevance 0.15

General Comments

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