INT251431

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0.14

cytoplasm (Gnat3, Gucy1b2) cytosol (Gucy1b2) signal transduction (Gnat3) ion binding (Gucy1b2) GTPase activity (Gnat3) signal transducer activity (Gnat3)

Gnat3 (Mus musculus) Gucy1b2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tolerance 14 78.40 addiction 5 73.32 Angina 1 28.68

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 98.92 Cv General 3 Under Development 1 28.68 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, activation of sGC by GTN has been accomplished in the presence of purified mitochondrial ALDH2, suggesting that the ALDH2-catalyzed decomposition of GTN yields NO (12); the physiological relevance of this observation is not clear yet.

Negative_regulation (accomplished) of GTN Positive_regulation (activation) of sGC

1) Confidence 0.02 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

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