INT251435

Context Info Confidence 0.22 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.15

signal transduction (Gnat3) plasma membrane (NPR1) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Gnat3 (Mus musculus) NPR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 1 98.64 tolerance 14 94.68 addiction 5 21.36

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 100.00 Cv General 3 Under Development 1 98.64 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GTN is thought to cause vasodilatation mainly by activation of soluble guanylate cyclase (sGC), which is stimulated by the binding of NO to a regulatory heme group.

GTN Positive_regulation (activation) of guanylate cyclase associated with increased venous pressure under development

1) Confidence 0.22 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.20 Pain Relevance 0.15

General Comments

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