INT251453

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnc1) transmembrane transport (Kcnc1)
Anatomy Link Frequency
neuronal 1
neurons 1
Kcnc1 (Mus musculus)
Dpp10 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 3 71.60 Quite High
Pyramidal cell 24 63.56 Quite High
Hippocampus 15 60.40 Quite High
addiction 3 44.72 Quite Low
Pain 3 38.60 Quite Low
repetitive firing 3 23.36 Low Low
Thalamus 3 16.32 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 72.76 Quite High
Disease 9 55.84 Quite High
Pain 3 38.60 Quite Low
Epilepsy 3 38.24 Quite Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 3 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In heterologous cells, DPP6 and DPP10 can interact with all three Kv4 proteins, however, in-situ hybridization studies showed that the two DPPL genes tended to be expressed in different neurons, with neuronal populations expressing mainly Kv4.2 containing DPP6 mRNAs, while DPP10 was the predominant DPPL in cells expressing Kv4.3, although exceptions to this pattern were noted (Nadal et al., 2006; Zagha et al., 2005).
Kv4 Binding (interact) of DPP10 in neuronal
1) Confidence 0.20 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.12 Pain Relevance 0.03
As discussed earlier, the analysis of mRNA distribution suggests that instead, the Kv4 channels in these neurons are mainly associated with DPP10 (Zagha et al., 2005).
Kv4 Binding (associated) of DPP10 in neurons
2) Confidence 0.17 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.15
First, the finding that DPP6 and DPP10 associate and modulate Kv4 channels is surprising, since all other known DPPs are enzymes and there is no precedent for these proteins functioning as modulators of other membrane proteins.
Kv4 Binding (associate) of DPP10
3) Confidence 0.14 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.06 Pain Relevance 0

General Comments

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