INT251469

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.11
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (INS, SHBG) extracellular space (INS) small molecule metabolic process (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 2
liver 2
INS (Homo sapiens)
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 4 85.92 High High
antagonist 2 64.32 Quite High
cytokine 1 15.76 Low Low
Dismenorea 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hirsutism 52 96.40 Very High Very High Very High
Hyperinsulinism 10 93.68 High High
Insulin Resistance 18 92.56 High High
Polycystic Ovary Syndrome 104 92.36 High High
Syndrome 13 90.04 High High
Hyperandrogenism 14 87.36 High High
Cardiovascular Disease 3 86.72 High High
Pre-eclampsia 100 82.64 Quite High
Ovarian Cancer 1 81.24 Quite High
Gestational Diabetes 1 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of SHBG is inhibited by insulin; therefore, low levels of SHBG are associated with elevated insulin levels.
insulin Negative_regulation (inhibited) of Gene_expression (Production) of SHBG
1) Confidence 0.11 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.41 Pain Relevance 0
At the same time insulin decreases the production of SHBG in the liver, leading to increased levels of free active testosterone.
insulin Negative_regulation (decreases) of Gene_expression (production) of SHBG in liver
2) Confidence 0.09 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.27 Pain Relevance 0.03
Furthermore, insulin is able to lower SHBG serum levels leading to an increase in free testosterone in the peripheral blood.[15]

DRUG-DEPENDENT HIRSUTISM

insulin Negative_regulation (lower) of Gene_expression (levels) of SHBG in blood associated with hirsutism
3) Confidence 0.09 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.42 Pain Relevance 0.04

General Comments

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