INT251516

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.81
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (REM1) GTPase activity (REM1)
Anatomy Link Frequency
eye 4
REM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 50 99.80 Very High Very High Very High
Hippocampus 63 92.48 High High
depression 98 86.28 High High
monoamine 14 60.64 Quite High
antidepressant 72 50.00 Quite Low
antagonist 2 48.88 Quite Low
Serotonin 24 47.00 Quite Low
Neurotransmitter 2 11.20 Low Low
sSRI 17 11.12 Low Low
sNRI 8 10.32 Low Low
Disease Link Frequency Relevance Heat
Sleep Disorders 54 99.14 Very High Very High Very High
Aids-related Complex 35 94.48 High High
Depression 123 86.28 High High
Premenstrual Syndrome 103 78.16 Quite High
Affective Disorder 15 55.44 Quite High
Recurrence 16 5.00 Very Low Very Low Very Low
Depressive Disorder 14 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Reprotox - General 2 8 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast agomelatine did not change rapid eye movement (REM) latency, amount of REM, or REM density.49
Neg (not) Regulation (change) of Gene_expression (amount) of REM in eye
1) Confidence 0.20 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.35 Pain Relevance 0.15
In contrast agomelatine did not change rapid eye movement (REM) latency, amount of REM, or REM density.49
Neg (not) Regulation (change) of Gene_expression (amount) of REM in eye
2) Confidence 0.20 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.35 Pain Relevance 0.15
Responders in this study showed improved mood scores during the LP after early-SD, which were significantly correlated with changes in REM sleep and ROL, indicating REM parameters to be important for the therapeutic effects of SD.
Regulation (changes) of Gene_expression (sleep) of REM associated with sleep disorders
3) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.87 Pain Relevance 0
Despite the link between cortical IEG upregulation and post-experience REM sleep, analysis of the relation between IEG expression in S1 and time spent in REM sleep within 60?
Regulation (spent) of Gene_expression (sleep) of REM associated with primary somatosensory cortex
4) Confidence 0.03 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.23 Pain Relevance 0.60
Similar effects were seen for mean REM sleep bout durations in the post-MD period (Fig. 1C), which were significantly reduced in all three hypnotic-treated groups relative to VEH (effects of treatment on REM sleep and wake bout durations: F?
Regulation (effects) of Gene_expression (sleep) of REM
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699540 Disease Relevance 0 Pain Relevance 0.06

General Comments

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