INT25152

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 37
Total Number 45
Disease Relevance 53.56
Pain Relevance 8.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
adipose tissue 4
adipocytes 4
blood 3
plasma 2
coronary artery 1
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 731 100.00 Very High Very High Very High
Paracetamol 28 99.44 Very High Very High Very High
cytokine 312 99.38 Very High Very High Very High
Angina 39 97.36 Very High Very High Very High
Inflammatory mediators 28 97.24 Very High Very High Very High
Inflammatory marker 79 96.84 Very High Very High Very High
metalloproteinase 13 96.16 Very High Very High Very High
Chronic pancreatitis 1 96.12 Very High Very High Very High
Crohn's disease 260 95.56 Very High Very High Very High
methotrexate 84 92.56 High High
Disease Link Frequency Relevance Heat
Obesity 1864 100.00 Very High Very High Very High
INFLAMMATION 823 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 184 100.00 Very High Very High Very High
Alzheimer's Dementia 181 100.00 Very High Very High Very High
Aneurism 8 100.00 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 1 100.00 Very High Very High Very High
Hepatocellular Cancer 30 99.84 Very High Very High Very High
Periodontal Disease 50 99.76 Very High Very High Very High
Weight Loss 168 99.60 Very High Very High Very High
Fever 225 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abundantly expressed serum amyloid A (SAA) protein under chronic inflammatory conditions gives rise to insoluble aggregates of SAA derivatives in multiple organs resulting in reactive amyloid A (AA) amyloidosis, a consequence of rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, familial Mediterranean fever, and Castleman's disease.
Gene_expression (expressed) of SAA associated with spinal inflammation, crohn's disease, alzheimer's dementia, rheumatoid arthritis, fever, disease, inflammation and amyloidosis
1) Confidence 0.75 Published 2006 Journal J. Immunol. Section Abstract Doc Link 16888022 Disease Relevance 1.26 Pain Relevance 0.34
A-SAA appears to be produced in fat cells (or adipocytes) and then released into the blood.
Gene_expression (produced) of SAA in blood associated with obesity
2) Confidence 0.62 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.64 Pain Relevance 0.21
We demonstrate that A-SAA was highly and selectively expressed in human adipocytes.
Gene_expression (expressed) of SAA in adipocytes associated with obesity
3) Confidence 0.62 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.69 Pain Relevance 0.20
Sustained overproduction of SAA is a prerequisite for the development of AA amyloidosis, although the reasons for these remain unknown.
Gene_expression (overproduction) of SAA associated with amyloidosis
4) Confidence 0.61 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.88 Pain Relevance 0.16
Sustained overproduction of SAA is a prerequisite for the development of AA amyloidosis.
Gene_expression (overproduction) of SAA associated with amyloidosis
5) Confidence 0.61 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.71 Pain Relevance 0.24
With SAA intake at 100% RDA, APAP administration oxidized the plasma cysteine/cystine redox potential (E(h)CySS) but not the plasma GSH/GSSG redox potential (E(h)GSSG).
Gene_expression (intake) of SAA in plasma associated with paracetamol
6) Confidence 0.59 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20207721 Disease Relevance 0.07 Pain Relevance 1.05
METHODS AND RESULTS: We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina.
Gene_expression (levels) of SAA in plasma
7) Confidence 0.58 Published 1999 Journal Circulation Section Body Doc Link 10027805 Disease Relevance 0.10 Pain Relevance 0
Postembolization angiography showed total occlusion of the SAA.
Gene_expression (occlusion) of SAA associated with aneurism
8) Confidence 0.57 Published 2009 Journal J Nihon Med Sch Section Abstract Doc Link 20035097 Disease Relevance 0.96 Pain Relevance 0.14
Obese people have higher numbers of fat cells, which could by itself account for the higher blood levels of A-SAA, but the researchers also found that the average fat cell from an obese individual produces and secretes higher levels of A-SAA than fat cells from lean individuals.
Gene_expression (produces) of SAA in fat cells associated with obesity
9) Confidence 0.53 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.42 Pain Relevance 0.20
Serum A-SAA levels decreased significantly after weight loss in obese participants (

p = 0.006), as well as in those treated with rosiglitazone ( p = 0.033).

Gene_expression (levels) of SAA associated with weight loss and obesity
10) Confidence 0.53 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.86 Pain Relevance 0.24
They found that obese people had higher levels of A-SAA in their blood.
Gene_expression (levels) of SAA in blood associated with obesity
11) Confidence 0.53 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.63 Pain Relevance 0.21
When the researchers studied people who underwent weight loss, they found that A-SAA levels fell in response to weight loss, and this was associated with improvements in their metabolism.
Gene_expression (levels) of SAA associated with weight loss
12) Confidence 0.53 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.15 Pain Relevance 0.17
Conceivably, individuals who develop amyloid have an enzyme defect that cannot breakdown SAA-protein completely hence insoluble AA molecules were produced.
Neg (cannot) Gene_expression (produced) of SAA-protein associated with alzheimer's dementia
13) Confidence 0.53 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.44 Pain Relevance 0.17
Patients with chronic periodontal diseases had higher levels of SAA, the precursor protein of amyloid fiber in secondary amyloidosis, than patients without periodontal disease [22].
Gene_expression (levels) of SAA associated with amyloidosis, alzheimer's dementia and periodontal disease
14) Confidence 0.53 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 2.55 Pain Relevance 0.23
Sixty patients were studied with CHD (20 with stable angina, 20 with unstable angina and 20 with acute myocardial infarction) and 20 sex- and age-matched controls without coronary artery disease, by measuring plasma levels of SAA, CRP, plasma lipids and intracoronary arterial luminal wall temperature.
Gene_expression (levels) of SAA in coronary artery associated with angina, coronary artery disease and myocardial infarction
15) Confidence 0.52 Published 2000 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 10652189 Disease Relevance 1.69 Pain Relevance 0.52
Accordingly, improvements in systemic inflammation and insulin resistance with weight loss and rosiglitazone therapy may in part be mediated by decreases in adipocyte A-SAA production.


Gene_expression (production) of SAA in adipocyte associated with weight loss, inflammation and insulin resistance
16) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.62 Pain Relevance 0.30
The increased expression of A-SAA by adipocytes in obesity suggests that it may play a critical role in local and systemic inflammation and free fatty acid production and could be a direct link between obesity and its comorbidities, such as insulin resistance and atherosclerosis.
Gene_expression (expression) of SAA in adipocytes associated with inflammation, atherosclerosis, obesity and insulin resistance
17) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.08 Pain Relevance 0.24
SAA is an apolipoprotein constituent of high-density lipoprotein that is synthesized by hepatocytes under the transcriptional regulation of pro-inflammatory cytokins [2].
Gene_expression (synthesized) of SAA in hepatocytes associated with inflammation and disorder of lipid metabolism
18) Confidence 0.48 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.65 Pain Relevance 0.23
Examples of such changes are the fluctuations in the levels of CRP, SAA, TNF-?
Gene_expression (levels) of SAA
19) Confidence 0.47 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.70 Pain Relevance 0.20
Spearman correlation coefficients were used to explore the association of S100A12 with SAA and CRP values, CDAI and CAI, as well as disease duration.
Gene_expression (values) of SAA associated with disease
20) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.54 Pain Relevance 0.09

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