INT251550

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Csnk1e) kinase activity (Csnk1e) cytoplasm (Csnk1e)
Anatomy Link Frequency
tail 1
Csnk1e (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 21 89.88 High High
cytokine 6 58.00 Quite High
Inflammatory response 3 54.92 Quite High
Central nervous system 10 36.24 Quite Low
Multiple sclerosis 19 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Etanercept 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 95.24 Very High Very High Very High
INFLAMMATION 26 89.88 High High
Ventricular Remodeling 3 75.56 Quite High
Myocardial Infarction 18 72.36 Quite High
Injury 26 59.40 Quite High
Cicatrix 3 58.04 Quite High
Death 10 53.76 Quite High
Apoptosis 24 28.00 Quite Low
Fever 1 24.00 Low Low
Disease 51 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin gets phosphorylated at serine/threonine residues 33, 37 and 41 by Casein Kinase-1 and Glycogen Synthase Kinase-3?
Phosphorylation (phosphorylated) of Casein Kinase-1
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993965 Disease Relevance 0.64 Pain Relevance 0.03
This signaling is mediated, at least in part, through casein kinase 1 phosphorylation of the cytoplamsic tail of TNFR2 resulting in increased intracellular calcium levels and activation of p38 and MAP kinase pathways [46-48].
Phosphorylation (phosphorylation) of casein kinase 1 in tail
2) Confidence 0.07 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.20 Pain Relevance 0.13

General Comments

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