INT251555

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ripk1) mitochondrion (Ripk1) plasma membrane (Ripk1)
protein complex (Ripk1) kinase activity (Ripk1) cytoplasm (Ripk1)
Ripk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 84.96 Quite High
cytokine 6 49.92 Quite Low
Central nervous system 10 35.04 Quite Low
Inflammation 20 17.92 Low Low
Multiple sclerosis 19 5.00 Very Low Very Low Very Low
Etanercept 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Adalimumab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 98.52 Very High Very High Very High
Stress 1 97.44 Very High Very High Very High
Death 7 95.80 Very High Very High Very High
Targeted Disruption 17 85.80 High High
INFLAMMATION 24 84.56 Quite High
Hyperplasia 1 49.36 Quite Low
Necrosis 3 20.16 Low Low
Disease 51 5.00 Very Low Very Low Very Low
Demyelinating Disease 24 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to TNFR1-induced activation of stress-induced kinase signaling in contributing to apoptotic signaling, TNFR1 can be internalized after TNF binding and this leads to dissociation of the TRADD/TRAF2/RIP complex and association of Fas-associated DD (FADD), recruitment of pro-caspase 8, and formation of the death-inducing signaling complex (DISC), triggering activation of the executioner caspases through the extrinsic apoptosis pathway [34,35].
RIP Binding (dissociation) of associated with stress, apoptosis and death
1) Confidence 0.17 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.16 Pain Relevance 0.04

General Comments

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