INT251557

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.68
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
neuron 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 79.56 Quite High
Etanercept 7 75.44 Quite High
Hippocampus 11 74.96 Quite High
Intracerebroventricular 1 69.72 Quite High
cytokine 9 26.24 Quite Low
Central nervous system 15 24.16 Low Low
Inflammatory stimuli 1 6.80 Low Low
Multiple sclerosis 19 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 33 99.96 Very High Very High Very High
Targeted Disruption 69 99.56 Very High Very High Very High
Immunization 2 99.08 Very High Very High Very High
Disease 239 95.28 Very High Very High Very High
Cognitive Disorder 22 94.72 High High
Sprains And Strains 1 90.92 High High
INFLAMMATION 37 79.56 Quite High
Death 16 49.56 Quite Low
Disease Progression 7 48.52 Quite Low
Congenital Anomalies 3 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies from our laboratory and others applied genetic or immunization-based approaches to demonstrate that partial reduction of BACE1 suffices to attenuate A?
Negative_regulation (attenuate) of Spec (partial) Negative_regulation (reduction) of BACE1 associated with immunization
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.87 Pain Relevance 0
Interestingly, Singer and colleagues demonstrated that a partial reduction in BACE1 can improve amyloid neuropathology including the deposition of A?
Negative_regulation (improve) of Spec (partial) Negative_regulation (reduction) of BACE1 associated with alzheimer's dementia
2) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.53 Pain Relevance 0
In these transgenic mice, TNFR1 deletion reduces Aß pathology, microglia activation, BACE1 activity, neuron loss, and memory deficits compared to transgenic APP23 mice expressing normal levels of TNFR1 [176].
Negative_regulation (reduces) of Negative_regulation (loss) of BACE1 in neuron associated with targeted disruption
3) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.28 Pain Relevance 0.22

General Comments

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