INT251628

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN2D) nucleus (CDKN2D) cytoplasm (CDKN2D)
CDKN2D (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 4 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 99.90 Very High Very High Very High
Cancer 97 98.48 Very High Very High Very High
Retinoblastoma 1 97.78 Very High Very High Very High
Congenital Anomalies 6 97.34 Very High Very High Very High
Testicular Cancer 147 95.78 Very High Very High Very High
Gastrointestinal Neoplasms 3 94.80 High High
Carcinoma In Situ 8 89.12 High High
Seminoma 32 88.16 High High
Disease 28 74.12 Quite High
Isochromosomes 1 56.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many in vitro and in vivo studies demonstrated that polyphenols from green tea were anti-carcinogenic by inducing apoptosis and inhibiting cell-growth, cyclin-dependent kinase inhibitor and urokinase (an enzyme crucial for cancer growth) [1].
Negative_regulation (inhibiting) of cyclin-dependent kinase inhibitor associated with cancer and apoptosis
1) Confidence 0.15 Published 2008 Journal Chin Med Section Body Doc Link PMC2577676 Disease Relevance 0.41 Pain Relevance 0
In particular, TGCT has been shown to be associated with a characteristic series of abnormalities in the retinoblastoma pathway including upregulation of cyclin D2 and p27 and downregulation of RB1 and the cyclin-dependent kinase inhibitors of p16, p18, p19 and p21 [13].
Negative_regulation (inhibitors) of p19 associated with congenital anomalies, testicular cancer and retinoblastoma
2) Confidence 0.11 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.42 Pain Relevance 0

General Comments

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