INT25163

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.37
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL2RA) plasma membrane (IL2RA)
Anatomy Link Frequency
effector T-cells 5
arm 2
IL2R 2
NK cells 1
IL2RA (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 82 99.76 Very High Very High Very High
Multiple sclerosis 6 99.40 Very High Very High Very High
Inflammation 36 98.40 Very High Very High Very High
cytokine 131 89.12 High High
rheumatoid arthritis 12 73.92 Quite High
tolerance 8 57.88 Quite High
Inflammatory marker 3 47.68 Quite Low
Inflammatory mediators 1 43.20 Quite Low
headache 4 25.00 Low Low
Antihistamine 2 24.04 Low Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 73 99.76 Very High Very High Very High
Asthma 50 99.76 Very High Very High Very High
Demyelinating Disease 6 99.40 Very High Very High Very High
Arthritis 8 98.72 Very High Very High Very High
INFLAMMATION 38 98.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 98.08 Very High Very High Very High
Hypersensitivity 30 97.28 Very High Very High Very High
Disease 55 96.92 Very High Very High Very High
Cancer 547 94.88 High High
Mycosis Fungoides 12 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the expression of IL2R has been largely thought to be important in T-cell targeting of denileukin diftitox, strategies to upregulate IL2R expression have been explored.
Positive_regulation (upregulate) of Gene_expression (expression) of IL2R in IL2R
1) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.60 Pain Relevance 0
A potential drawback of both approaches is that activated, effector T-cells also transiently upregulate the expression of CD25 on their cell surface, therefore being at risk of depletion by strategies that target CD25.
Positive_regulation (upregulate) of Gene_expression (expression) of CD25 in effector T-cells
2) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.85 Pain Relevance 0.03
Due to the pro-inflammatory role of activated T-cells in asthmatic airways and the observed correlation of increased CD25 expression with asthma severity, attempts have been made to block this arm of allergic disease pathogenesis.
Positive_regulation (increased) of Gene_expression (expression) of CD25 in arm associated with asthma, inflammation, hypersensitivity and disease
3) Confidence 0.31 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.94 Pain Relevance 0.30
Since HTLV-1 can augment expression of CD25, we also re-analyzed the data without including CD25 expression in the definition of regulatory cells (i.e.
Positive_regulation (augment) of Gene_expression (expression) of CD25
4) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.33 Pain Relevance 0
Moreover, IL-2 mediates not only the proliferation of activated, effector T-cells and NK cells, but also the development and homeostasis of regulatory T-cells (Tregs), which constitutively express elevated levels of the IL-2R alpha (CD25) [71].
Positive_regulation (elevated) of Gene_expression (express) of IL-2R in effector T-cells
5) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.32 Pain Relevance 0.19
Increased levels of both IL-2 and sIL-2R were found in MS serum.
Positive_regulation (Increased) of Gene_expression (levels) of sIL-2R associated with multiple sclerosis
6) Confidence 0.16 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2504888 Disease Relevance 0.75 Pain Relevance 0.27
Moreover, IL-2 mediates not only the proliferation of activated, effector T-cells and NK cells, but also the development and homeostasis of regulatory T-cells (Tregs), which constitutively express elevated levels of the IL-2R alpha (CD25) [71].
Positive_regulation (elevated) of in NK cells Gene_expression (express) of IL-2R in effector T-cells
7) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.32 Pain Relevance 0.19
For example, although we observed increased levels of sIL2R in a JIA subtype equivalent to ERA in a study by Mangge et al [8], these concentrations were not significantly different from controls.
Positive_regulation (increased) of Gene_expression (levels) of sIL2R associated with arthritis
8) Confidence 0.01 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.26 Pain Relevance 0.74

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