INT251636

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 26
Disease Relevance 9.64
Pain Relevance 8.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bile 15
duodenum 1
Csf2rb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 1378 100.00 Very High Very High Very High
tolerance 468 100.00 Very High Very High Very High
Crohn's disease 26 98.80 Very High Very High Very High
Inflammation 130 21.04 Low Low
cytokine 52 7.64 Low Low
spastic colon 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1352 100.00 Very High Very High Very High
Disease 26 98.80 Very High Very High Very High
Gallbladder Disease 26 98.16 Very High Very High Very High
Infection 260 96.00 Very High Very High Very High
Stress 52 84.52 Quite High
Dislocations 52 33.68 Quite Low
INFLAMMATION 104 21.04 Low Low
Inflammatory Bowel Disease 104 18.48 Low Low
Functional Bowel Disorder 26 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both BilE+ and BilE- strains were detectable in faeces at approximately the same levels at 24 hours post inoculation.
Gene_expression (detectable) of BilE associated with sprains and strains
1) Confidence 0.33 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.45 Pain Relevance 0.16
Both BilE+ and BilE- strains were detectable in faeces at approximately the same levels at 24 hours post inoculation.
Gene_expression (detectable) of BilE associated with sprains and strains
2) Confidence 0.33 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.45 Pain Relevance 0.16
Here cloning and expression of BilE in B. breve and L. lactis resulted in a 2.5 to 3.5-log increased tolerance of porcine bile.
Gene_expression (expression) of BilE in bile associated with bile and tolerance
3) Confidence 0.33 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.34 Pain Relevance 0.56
Survival of B. breve in the murine GI tract was also significantly enhanced through expression of BilE.
Gene_expression (expression) of BilE
4) Confidence 0.33 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.48 Pain Relevance 0.35
We show that L. lactis expressing cloned BilE demonstrates significantly enhanced survival in the GI tract of mice (as measured in faeces) relative to the wild-type L. lactis strain.
Gene_expression (expressing) of BilE associated with sprains and strains
5) Confidence 0.29 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.52 Pain Relevance 0.36
Here we implement the patho-biotechnology concept to improve the in vivo and in vitro bile resistance of a potential probiotic strain, B. breve UCC2003, as well as the food isolate L. lactis, through cloning and expression of a bile tolerance system in these organisms.
Gene_expression (expression) of bile in bile associated with bile, tolerance and sprains and strains
6) Confidence 0.29 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.49 Pain Relevance 0.30
B. breve UCC2003 colonies containing pNZ8048-bilE+ and pNZ8048-bilE- and L. lactis NZ9000 colonies containing pNZ8048-bilE+and pNZ8048-bilE- were first cultured in MRS broth containing 4 ?
Gene_expression (containing) of pNZ8048-bilE
7) Confidence 0.29 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.16 Pain Relevance 0
B. breve UCC2003 colonies containing pNZ8048-bilE+ and pNZ8048-bilE- and L. lactis NZ9000 colonies containing pNZ8048-bilE+and pNZ8048-bilE- were first cultured in MRS broth containing 4 ?
Gene_expression (containing) of pNZ8048-bilE
8) Confidence 0.29 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.16 Pain Relevance 0
B. breve UCC2003 colonies containing pNZ8048-bilE+ and pNZ8048-bilE- and L. lactis NZ9000 colonies containing pNZ8048-bilE+and pNZ8048-bilE- were first cultured in MRS broth containing 4 ?
Gene_expression (containing) of pNZ8048-bilE
9) Confidence 0.29 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.10 Pain Relevance 0
B. breve UCC2003 colonies containing pNZ8048-bilE+ and pNZ8048-bilE- and L. lactis NZ9000 colonies containing pNZ8048-bilE+and pNZ8048-bilE- were first cultured in MRS broth containing 4 ?
Gene_expression (containing) of pNZ8048-bilE
10) Confidence 0.29 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.10 Pain Relevance 0
Sleator et al., 2005, showed that bilE is involved in bile exclusion and not in osmotolerance as previously believed.
Gene_expression (exclusion) of bile in bile associated with bile
11) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.28 Pain Relevance 0.58
Due to difficulty in obtaining human bile; porcine bile was used to examine the bile tolerance of B. breve bilE+ and L. lactis bilE+.
Spec (examine) Gene_expression (tolerance) of bilE in bile associated with bile and tolerance
12) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.20 Pain Relevance 0.54
Proof that the operon was heterologously expressed in both bacterial strains was evident as a single mRNA transcript was obtained by reverse transcription polymerase chain reaction (RT-PCR) analysis (Fig. 2) also in vitro studies showing increased bile resistance supports this by indicating that the bile resistance locus was functional.
Gene_expression (resistance) of bile in bile associated with bile and sprains and strains
13) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.10 Pain Relevance 0.47
Due to difficulty in obtaining human bile; porcine bile was used to examine the bile tolerance of B. breve bilE+ and L. lactis bilE+.
Spec (examine) Gene_expression (tolerance) of bile in bile associated with bile and tolerance
14) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.14 Pain Relevance 0.54
These data provide proof of concept that bile tolerance in these strains can be significantly enhanced through rational genetic manipulation.
Gene_expression (tolerance) of bile in bile associated with bile, tolerance and sprains and strains
15) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.44 Pain Relevance 0.55
In contrast L. lactis BilE+was detectable at high levels in murine faeces at days 2 and 3 post-inoculation.
Gene_expression (detectable) of BilE
16) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.47 Pain Relevance 0.09
Here we implement the patho-biotechnology concept to improve the in vivo and in vitro bile resistance of a potential probiotic strain, B. breve UCC2003, as well as the food isolate L. lactis, through cloning and expression of a bile tolerance system in these organisms.
Gene_expression (expression) of bile in bile associated with bile, tolerance and sprains and strains
17) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.50 Pain Relevance 0.31
Resistance to Bile
Gene_expression (Resistance) of Bile in Bile associated with bile
18) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.10 Pain Relevance 0.14
Similar results were seen in experiments carried out using bovine bile (oxgall) (data not shown).


Gene_expression (using) of bile in bile associated with bile
19) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.50 Pain Relevance 0.50
Due to difficulty in obtaining human bile; porcine bile was used to examine the bile tolerance of B. breve bilE+ and L. lactis bilE+.
Spec (examine) Gene_expression (tolerance) of bilE in bile associated with bile and tolerance
20) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.15 Pain Relevance 0.54

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