INT251639

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.73
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bile 6
Csf2rb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 212 100.00 Very High Very High Very High
tolerance 72 100.00 Very High Very High Very High
Crohn's disease 4 83.96 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
spastic colon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 208 100.00 Very High Very High Very High
Stress 8 86.32 High High
Disease 4 83.96 Quite High
Infection 40 71.28 Quite High
Gallbladder Disease 4 41.92 Quite Low
Dislocations 8 34.08 Quite Low
Inflammatory Bowel Disease 16 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Survival of B. breve in the murine GI tract was also significantly enhanced through expression of BilE.
Positive_regulation (enhanced) of Gene_expression (expression) of BilE
1) Confidence 0.21 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.48 Pain Relevance 0.35
These data provide proof of concept that bile tolerance in these strains can be significantly enhanced through rational genetic manipulation.
Positive_regulation (enhanced) of Gene_expression (tolerance) of bile in bile associated with bile, tolerance and sprains and strains
2) Confidence 0.19 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.46 Pain Relevance 0.55
Proof that the operon was heterologously expressed in both bacterial strains was evident as a single mRNA transcript was obtained by reverse transcription polymerase chain reaction (RT-PCR) analysis (Fig. 2) also in vitro studies showing increased bile resistance supports this by indicating that the bile resistance locus was functional.
Positive_regulation (increased) of Gene_expression (resistance) of bile in bile associated with bile and sprains and strains
3) Confidence 0.19 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2577680 Disease Relevance 0.10 Pain Relevance 0.47
In vitro bile tolerance of both strains was significantly enhanced (P < 0.001), following heterologous expression of the Listeria monocytogenes bile resistance mechanism BilE.
Positive_regulation (enhanced) of Gene_expression (expression) of bile in bile associated with bile, tolerance and sprains and strains
4) Confidence 0.17 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2577680 Disease Relevance 0.69 Pain Relevance 0.29

General Comments

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