INT25166

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 5.94
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 5
neuronal 1
nerves 1
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 96.60 Very High Very High Very High
Migraine 6 96.48 Very High Very High Very High
antagonist 11 96.28 Very High Very High Very High
cINOD 15 95.80 Very High Very High Very High
COX-2 inhibitor 21 92.84 High High
Arthritis 3 92.56 High High
Inflammatory response 7 90.24 High High
Inflammation 24 89.84 High High
agonist 49 87.12 High High
noradrenaline 7 87.04 High High
Disease Link Frequency Relevance Heat
Stress 44 100.00 Very High Very High Very High
Hemorrhage 10 100.00 Very High Very High Very High
Sepsis 39 99.48 Very High Very High Very High
Injury 9 99.32 Very High Very High Very High
Targeted Disruption 6 99.04 Very High Very High Very High
Coronary Artery Disease 16 97.04 Very High Very High Very High
Aging 1 96.96 Very High Very High Very High
Headache 6 96.48 Very High Very High Very High
Disease 14 96.28 Very High Very High Very High
Shock 1 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 and TXA2 levels and their modulation by nicardipine, a calcium blocking agent, have been studied in patients suffering from migraine.
Regulation (modulation) of TXA2 associated with migraine
1) Confidence 0.43 Published 1989 Journal Headache Section Abstract Doc Link 2793453 Disease Relevance 0.44 Pain Relevance 0.48
These data show that propranolol therapy does not affect platelet-released beta thromboglobulin or TXA2 at rest, but significantly reduces the capability of platelets to generate TXA2 in vitro.
Neg (not) Regulation (affect) of TXA2 in platelets
2) Confidence 0.32 Published 1982 Journal Circulation Section Abstract Doc Link 6216027 Disease Relevance 0.14 Pain Relevance 0
Regulation of Thromboxane Receptor Signaling at Multiple Levels by Oxidative Stress-Induced Stabilization, Relocation and Enhanced Responsiveness

Background

Regulation (Regulation) of Thromboxane Receptor associated with stress
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2939892 Disease Relevance 0.10 Pain Relevance 0.03
The evidence that picotamide almost completely inhibits platelet aggregation induced by the TxA2 analogous U46619 suggested that this drug also has an inhibitory effect on TxA2 receptors (Berrettini et al 1990).
Regulation (effect) of TxA2 in platelet
4) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.10 Pain Relevance 0.09
COX-mediated neuronal injury is presumed be due to downstream effects of one or more prostaglandin products including PGE2, PGD2, PGF2alpha, PGI2 (prostacylin) and TXA2 (thromboxane) that effect cellular changes through activation of specific prostaglandin receptor subtypes and second messenger systems.
Regulation (effects) of TXA2 in neuronal associated with injury
5) Confidence 0.25 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17901552 Disease Relevance 1.43 Pain Relevance 0.35
Thus, the fact that picotamide is more effective in reducing microalbuminuria induced by stress-test than at rest suggests that the vasoconstrictor properties of TxA2 may be responsible for its physiopathological action on glomerular activity.
Spec (may) Regulation (responsible) of TxA2 associated with stress
6) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.99 Pain Relevance 0.03
Alterations in platelet-generated thromboxane A2 (TXA2) and vessel wall-generated prostacyclin (PGI2) have been associated with myocardial ischemia.
Regulation (Alterations) of TXA2 in platelet associated with coronary artery disease and ischemia
7) Confidence 0.23 Published 1983 Journal Am. Heart J. Section Abstract Doc Link 6344604 Disease Relevance 0.40 Pain Relevance 0.05
Alterations in platelet-generated thromboxane A2 (TXA2) and vessel wall-generated prostacyclin (PGI2) have been associated with myocardial ischemia.
Regulation (Alterations) of thromboxane A2 in platelet associated with coronary artery disease and ischemia
8) Confidence 0.23 Published 1983 Journal Am. Heart J. Section Abstract Doc Link 6344604 Disease Relevance 0.40 Pain Relevance 0.05
Mice with an absent prostaglandin receptor (IPKO) should mimic the clinical effect of taking COX-2 agents, as these drugs would inhibit prostaglandin production without affecting TXA2.
Neg (without) Regulation (affecting) of TXA2
9) Confidence 0.21 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.66 Pain Relevance 0.20
Here we examined the effects of oxidative stress on the thromboxane receptor to understand the molecular and cellular consequences of exposure to ROS on thromboxane receptor activity.
Spec (examined) Regulation (effects) of thromboxane receptor associated with stress
10) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.41 Pain Relevance 0.14
Ibuprofen, at concentrations up to 1 mM, had no effect on the activities of PGI2 synthase, TXA2 synthase of GSH-dependent PGE2 isomerase, whereas indomethacin selectively inhibited PGI2 synthase activity at 5 X 10(-4) M and 10(-3) M.
Neg (no) Regulation (effect) of TXA2
11) Confidence 0.11 Published 1989 Journal Mol. Cell. Biochem. Section Abstract Doc Link 2505061 Disease Relevance 0 Pain Relevance 0.14
A randomized, double-blind, placebo-controlled trial was conducted in 79 healthy adults to compare the effects of once-daily therapeutic (7.5 mg, 15 mg) and supratherapeutic (30 mg) doses of meloxicam with extended-release indomethacin (Indo-ER 75 mg once daily) on bleeding time, TxA2 formation, and platelet aggregation.
Regulation (effects) of TxA2 in platelet associated with hemorrhage
12) Confidence 0.08 Published 2002 Journal J Clin Pharmacol Section Abstract Doc Link 12162470 Disease Relevance 0.54 Pain Relevance 0.40
Double immunofluorescence staining using protein gene product 9.5, tyrosine hydroxylase, EP(3) receptor and TP receptor antibodies suggested the localization of EP(3) or TP receptors on adrenergic nerves in the porcine uterus.
Regulation (using) of TP receptor in nerves
13) Confidence 0.02 Published 2008 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 18403225 Disease Relevance 0 Pain Relevance 0.49
Regulation of thromboxane A2 and free radical formation were initially proposed as mechanisms of action [83].
Regulation (Regulation) of thromboxane A2
14) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.34 Pain Relevance 0.03

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