INT251665

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LRP5, Ache) nuclear envelope (Ache) Golgi apparatus (Ache)
endoplasmic reticulum (LRP5) cytoplasm (Ache) extracellular space (Ache)
LRP5 (Homo sapiens)
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 30 99.72 Very High Very High Very High
Neurotransmitter 10 98.60 Very High Very High Very High
headache 4 43.12 Quite Low
Nicotine 4 19.80 Low Low
sodium channel 24 5.00 Very Low Very Low Very Low
Dopamine 24 5.00 Very Low Very Low Very Low
Action potential 12 5.00 Very Low Very Low Very Low
Substantia nigra 8 5.00 Very Low Very Low Very Low
Serotonin 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 162 75.48 Quite High
Toxicity 52 74.64 Quite High
Poisoning 48 55.84 Quite High
Syndrome 6 52.44 Quite High
Congenital Anomalies 10 48.32 Quite Low
Aging 6 45.48 Quite Low
Headache 4 43.12 Quite Low
Sleep Disorders 2 42.32 Quite Low
Cognitive Disorder 10 42.00 Quite Low
Dizziness 4 41.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetylcholine and other neurotransmitters play unique trophic roles in the development of the CNS [37,38], and inhibition of AChE by OPs and the resulting accumulation of acetylcholine may then conceivably disturb this development.
OPs Negative_regulation (inhibition) of AChE associated with neurotransmitter and central nervous system
1) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.18 Pain Relevance 0.10
Inhibition of AChE by OPs is obtained by the P = O moiety forming a covalent bond with the active site of the enzyme.
OPs Negative_regulation (Inhibition) of AChE
2) Confidence 0.20 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.20 Pain Relevance 0.09

General Comments

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