INT251679

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 10.37
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
muscles 4
glial cells 2
brain 2
astrocytes 2
body 2
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 16 99.68 Very High Very High Very High
Dopamine 64 98.16 Very High Very High Very High
Demyelination 32 90.24 High High
cytokine 17 85.84 High High
Neurotransmitter 16 83.60 Quite High
potassium channel 24 78.48 Quite High
Spinal cord 83 76.96 Quite High
addiction 24 59.88 Quite High
Multiple sclerosis 48 54.60 Quite High
Substantia nigra 16 48.48 Quite Low
Disease Link Frequency Relevance Heat
Atrophy 56 99.88 Very High Very High Very High
Creutzfeldt Jakob Disease 80 99.44 Very High Very High Very High
Lewy Body Disease 24 98.56 Very High Very High Very High
Disease 568 98.52 Very High Very High Very High
Neuromyelitis Optica 484 98.52 Very High Very High Very High
Necrosis 16 97.96 Very High Very High Very High
Motor Neuron Diseases 152 97.86 Very High Very High Very High
Cerebral Amyloid Angiopathy 40 97.16 Very High Very High Very High
Alzheimer's Dementia 48 96.96 Very High Very High Very High
Prion Diseases 48 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initiation of immunosuppression was apparently followed by a marked and rapid decline of both AQP4-Ab levels and flare rates in all of our patients.
Negative_regulation (decline) of Gene_expression (levels) of AQP4
1) Confidence 0.38 Published 2008 Journal Brain Section Body Doc Link PMC2577801 Disease Relevance 0.86 Pain Relevance 0.04
ALS), there has been a very few data on the expression of AQP4; in human muscles with neurogenic atrophy, the expression of AQP4 was down-regulated.
Negative_regulation (down) of Gene_expression (expression) of AQP4 in muscles associated with atrophy and motor neuron diseases
2) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.20 Pain Relevance 0.03
The results presented by these authors show a down-regulation of AQP4 expression in striatal glial cells in vitro mediated by DA.
Negative_regulation (regulation) of Gene_expression (expression) of AQP4 in glial cells associated with dopamine
3) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.37 Pain Relevance 0.25
Moreover, in support to this hypothesis, Wilcock and colleagues found that gene expression of Kir4.1, AQP4 and dystrophin were significantly reduced also in human post-mortem diagnosed AD brain with moderate and severe CAA.
Negative_regulation (reduced) of Gene_expression (expression) of AQP4 in brain associated with cerebral amyloid angiopathy and disease
4) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.09 Pain Relevance 0.04
ALS), there has been a very few data on the expression of AQP4; in human muscles with neurogenic atrophy, the expression of AQP4 was down-regulated.
Negative_regulation (regulated) of Gene_expression (expression) of AQP4 in muscles associated with atrophy and motor neuron diseases
5) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.20 Pain Relevance 0.03
Furthermore, Rodriguez and colleagues [79] analyzed AQP1 and AQP4 expression in the cerebral cortex of CJD patients compared to that in cases with AD and diffuse Lewy body disease (DLB).
Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of AQP4 in body associated with creutzfeldt jakob disease, lewy body disease, disease and cerebral cortex
6) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.46 Pain Relevance 0.05
In a comparable study, Misu and colleagues [65] showed some NMO lesions in which myelinated fibers were relatively preserved despite the loss of AQP4 staining, suggesting that the loss of AQP4 did not reflect necrosis and cell loss.
Negative_regulation (loss) of Gene_expression (staining) of AQP4 associated with necrosis and neuromyelitis optica
7) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.33 Pain Relevance 0.25
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Negative_regulation (levels) of Gene_expression (levels) of AQP4 associated with creutzfeldt jakob disease, lewy body disease and disease
8) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.49 Pain Relevance 0.05
A potential explanation for the loss of AQP4 and Kir4.1 channels is that they share a common anchoring protein that is affected by vascular amyloid deposition: the Dp71 dystrophin protein, localized on perivascular astrocytes [40].
Negative_regulation (loss) of Gene_expression (channels) of AQP4 in astrocytes associated with alzheimer's dementia
9) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.36 Pain Relevance 0.03

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