INT251704

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.68
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ache, Acot1) mitochondrion (Acot1) nuclear envelope (Ache)
Golgi apparatus (Ache) lipid metabolic process (Acot1) cytosol (Acot1)
Anatomy Link Frequency
synapses 4
Ache (Rattus norvegicus)
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 12 98.80 Very High Very High Very High
anesthesia 2 94.24 High High
cerebral cortex 16 71.76 Quite High
Endogenous opioid 2 59.20 Quite High
monoamine 2 57.56 Quite High
Bile 8 57.12 Quite High
Pyramidal cell 12 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 22 99.76 Very High Very High Very High
Encephalopathy 2 85.48 High High
Hepatic Encephalopathy 34 78.48 Quite High
Liver Failure 20 73.76 Quite High
Liver Disease 16 66.52 Quite High
End Stage Liver Disease 2 49.52 Quite Low
Cirrhosis 38 39.20 Quite Low
Urological Neuroanatomy 14 5.00 Very Low Very Low Very Low
Hyperammonemia 8 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of ACh are continuously regulated by choline acetyltransferase (ChAT), the enzyme which synthesizes ACh and by acetylcholinesterase (AChE), which rapidly degrades the neurotransmitter at cholinergic synapses terminating synaptic transmission.
AChE Regulation (regulated) of Gene_expression (levels) of ACh in synapses associated with neurotransmitter
1) Confidence 0.08 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.84 Pain Relevance 0.43
The levels of ACh are continuously regulated by choline acetyltransferase (ChAT), the enzyme which synthesizes ACh and by acetylcholinesterase (AChE), which rapidly degrades the neurotransmitter at cholinergic synapses terminating synaptic transmission.
acetylcholinesterase Regulation (regulated) of Gene_expression (levels) of ACh in synapses associated with neurotransmitter
2) Confidence 0.08 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.84 Pain Relevance 0.43

General Comments

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