INT25172

Context Info Confidence 0.68 First Reported 1983 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 9 Total Number 11 Disease Relevance 3.01 Pain Relevance 1.02

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC) nucleolus (PGC) nucleus (PGC)

Anatomy Link Frequency lumen 4 peptic cells 4 PGC (Homo sapiens)

Pain Link Frequency Relevance Heat peptic ulcer disease 8 98.72 cINOD 4 96.88 adenocard 1 85.56 Analgesic 1 80.20 Inflammation 2 79.76

Disease Link Frequency Relevance Heat Gastritis 3 99.98 Adenocarcinoma 2 99.28 Ulcers 13 98.72 Disease 10 98.20 Duodenal Ulcer 4 97.12 Injury 4 96.00 Stress 2 94.56 Alagille Syndrome 2 94.16 Peptic Ulcer 1 93.68 INFLAMMATION 2 79.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We conclude that indomethacin potentiates basal and secretagogue-stimulated pepsinogen secretion by dispersed human peptic cells and this might be an additional mechanism of NSAID-induced gastric injury.

Positive_regulation (potentiates) of Localization (secretion) of pepsinogen in peptic cells associated with injury and cinod

1) Confidence 0.68 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.10 Pain Relevance 0.10

Increase of pepsinogen secretion was dependent on extracellular calcium because potentiation was abolished by calcium depletion of the medium.

Positive_regulation (Increase) of Localization (secretion) of pepsinogen

2) Confidence 0.68 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.08 Pain Relevance 0.08

Low concentrations of indomethacin (10(-8)-10(-10) M) stimulated basal pepsinogen secretion.

Positive_regulation (stimulated) of Localization (secretion) of pepsinogen

3) Confidence 0.68 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.05 Pain Relevance 0.06

We conclude that indomethacin potentiates basal and secretagogue-stimulated pepsinogen secretion by dispersed human peptic cells and this might be an additional mechanism of NSAID-induced gastric injury.

Positive_regulation (stimulated) of Localization (secretion) of pepsinogen in peptic cells associated with injury and cinod

4) Confidence 0.68 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.10 Pain Relevance 0.10

This will facilitate the study of pepsin secretion, particularly in patients with peptic ulcer disease.

Positive_regulation (facilitate) of Localization (secretion) of pepsin associated with peptic ulcer disease and disease

5) Confidence 0.50 Published 1989 Journal J. Chromatogr. Section Abstract Doc Link 2506210 Disease Relevance 0.20 Pain Relevance 0.10

Vacuolating toxin from Helicobacter pylori activates cellular signaling and pepsinogen secretion in human gastric adenocarcinoma cells.

Positive_regulation (activates) of Localization (secretion) of pepsinogen associated with adenocarcinoma and gastritis

6) Confidence 0.46 Published 1996 Journal FEBS Lett. Section Title Doc Link 8980135 Disease Relevance 0.56 Pain Relevance 0.11

CONCLUSIONS: Both pentagastrin and hypoglycaemia caused similar maximal secretion rates of pepsin 1, but hypoglycaemia caused greater secretion rates of total pepsin.

Positive_regulation (caused) of Localization (secretion) of pepsin

7) Confidence 0.43 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: Both pentagastrin and hypoglycaemia caused similar maximal secretion rates of pepsin 1, but hypoglycaemia caused greater secretion rates of total pepsin.

Positive_regulation (caused) of Localization (secretion) of pepsin

8) Confidence 0.43 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0

The mechanism of antiulcer effect could either be due to decrease in acid-pepsin secretion and augmentation of mucin secretion as observed with ethanol extract, while petroleum ether extract might be producing the effect by virtue of its anti-stress activity.

Positive_regulation (augmentation) of Localization (secretion) of acid-pepsin associated with stress

9) Confidence 0.02 Published 1997 Journal Indian J. Exp. Biol. Section Abstract Doc Link 9475056 Disease Relevance 0.50 Pain Relevance 0.16

One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.

Positive_regulation (elevated) of Localization (secreted) of pepsin precursor in lumen associated with duodenal ulcer

10) Confidence 0.01 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.71 Pain Relevance 0.16

One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.

Spec (appearing) Positive_regulation (appearing) of Localization (secreted) of pepsin precursor in lumen associated with duodenal ulcer

11) Confidence 0.01 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.72 Pain Relevance 0.16

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