INT25173

Context Info Confidence 0.17 First Reported 1989 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.59 Pain Relevance 0.80

Anatomy Link Frequency brain 1 bile 1 H2-M3 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 11 93.20 narcan 5 91.72 withdrawal 1 80.36 Opioid 1 75.00 Pain 1 25.00

Disease Link Frequency Relevance Heat Sprains And Strains 7 97.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was a correlation between formation rate of M3G and N3G (r = 0.65 brain and r = 0.73 liver).

Localization (rate) of M3G in brain

1) Confidence 0.17 Published 1989 Journal Pain Section Abstract Doc Link 2506504 Disease Relevance 0.59 Pain Relevance 0.54

Loss of biliary M3G secretion in Mrp2(-/-) mice results in its increased sinusoidal transport that can be attributed to Mrp3.

Localization (secretion) of M3G

2) Confidence 0.05 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485564 Disease Relevance 0 Pain Relevance 0.26

Of the M3G and M6G formed during a single passage, 19 +/- 11% and 9 +/- 9%, respectively, was excreted into bile; the values were significantly different (P = 0.002).

Localization (excreted) of M3G in bile

3) Confidence 0.02 Published 1997 Journal Pharm. Res. Section Body Doc Link 9279882 Disease Relevance 0 Pain Relevance 0

General Comments

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