INT251734

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.93
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD70) signal transduction (CD70) extracellular space (CD70)
plasma membrane (CD70) cell-cell signaling (CD70)
Anatomy Link Frequency
B lymphocytes 1
CD70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 267 99.48 Very High Very High Very High
Pain 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Headache 222 99.48 Very High Very High Very High
Migraine With Aura 48 96.80 Very High Very High Very High
Migraine Without Aura 69 94.64 High High
Cadasil 75 90.28 High High
Disease 9 75.32 Quite High
Epilepsy 6 72.20 Quite High
Congenital Anomalies 3 15.40 Low Low
Dementia 6 13.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TNFSF7 gene (Tumor Necrosis Factor Ligand Superfamily, member 7) localized on C19p13 is a surface antigen found on activated, but not resting, T and B lymphocytes [21].
Localization (localized) of TNFSF7 in B lymphocytes associated with necrosis and cancer
1) Confidence 0.69 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 1.22 Pain Relevance 0.62
Since TNFSF7 is localized to the same migraine susceptibility area at C19p13 and shows homology to the ligands of the TNF-alpha and TNF-beta genes (both localized at C6p21.3), we decided to also investigate this gene for involvement in migraine.
Localization (localized) of TNFSF7 associated with migraine
2) Confidence 0.64 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 1.19 Pain Relevance 0.84
The TNFSF7 gene also localized to the C19p13 region did not show any association with typical migraine or the MA subtype, however a weak association was found with MO affected individuals.
Localization (localized) of TNFSF7 associated with migraine with aura, migraine and migraine without aura
3) Confidence 0.60 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 1.52 Pain Relevance 0.96

General Comments

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