INT251767

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
central nervous system 2


Pain Term Frequency Confidence Heat
adenocard 10 98.48 Very High Very High Very High
Central nervous system 2 96.58 Very High Very High Very High
cytokine 39 91.04 High High
Inflammation 26 85.56 High High
Inflammatory stimuli 5 73.52 Quite High
tolerance 2 67.92 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Insulin Resistance 10 86.48 High High
INFLAMMATION 33 85.56 High High
Obesity 113 85.04 High High
Necrosis 3 50.00 Quite Low
Cancer 5 50.00 Quite Low
Hypertension 3 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 1 5.00 Very Low Very Low Very Low
Weight Loss 4 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lipolytic mechanisms associated with caffeine ingestion include the following [16]: 1) central nervous system stimulation resulting in an increase in circulating epinephrine, 2) an inhibition in intracellular phosphodiesterase activity leading to sustained intracellular cAMP and activated perilipin and HSL levels, and 3) the antagonism of peripheral adenosine (A1) receptors which further increases intracellular cAMP levels [17].
Positive_regulation (activated) of Gene_expression (levels) of perilipin in central nervous system associated with adenocard and central nervous system
1) Confidence 0.49 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2579279 Disease Relevance 0.14 Pain Relevance 0.21
–induced lipolysis is the downregulation of perilipin through, at least in part, ERK activation (10), suggesting that the Tpl2/ERK signaling pathway could negatively regulate perilipin expression.
Positive_regulation (regulate) of Gene_expression (expression) of perilipin
2) Confidence 0.49 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.56 Pain Relevance 0.28

General Comments

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