INT251774

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.06
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TXK, EGFR) plasma membrane (TXK, EGFR) cytoplasm (TXK, EGFR)
DNA binding (TXK) extracellular space (EGFR) endosome (EGFR)
Anatomy Link Frequency
lung 2
TXK (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 62.12 Quite High
antagonist 1 28.72 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 1 98.28 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 84 97.96 Very High Very High Very High
Breast Cancer 59 94.32 High High
Toxicity 14 65.00 Quite High
Headache 4 62.12 Quite High
Vomiting 13 61.72 Quite High
Diarrhoea 14 61.40 Quite High
Cancer 35 59.00 Quite High
Disease 22 57.04 Quite High
Lymphatic System Cancer 1 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PF-00299804 is an orally active pan-HER tyrosine kinase inhibitor which specifically and irreversibly binds to and inhibits HER1, HER2 and HER4 which was evaluated in non-small cell lung cancer patients at ASCO 2008 but also exhibits potential activity in HER2 positive breast cancer patients.[67]
Negative_regulation (inhibitor) of tyrosine kinase in lung Negative_regulation (inhibits) of HER1 associated with lung cancer and breast cancer
1) Confidence 0.07 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.06 Pain Relevance 0.06

General Comments

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