INT251827

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.94
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (POLG) cell death (POLG) aging (POLG)
DNA binding (POLG) nucleotidyltransferase activity (POLG) DNA metabolic process (POLG)
POLG (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 80.48 Quite High
Pain 3 45.28 Quite Low
peripheral neuropathy 4 34.96 Quite Low
imagery 21 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 207 99.56 Very High Very High Very High
Disease 20 99.32 Very High Very High Very High
Parkinson's Disease 24 98.84 Very High Very High Very High
Premature Aging 3 97.72 Very High Very High Very High
Mitochondrial Disorders 11 96.92 Very High Very High Very High
Lifespan 54 89.80 High High
Chronic Progressive External Ophthalmoplegia 11 88.08 High High
Infertility 9 87.28 High High
Targeted Disruption 3 87.20 High High
Muscle Weakness 9 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over 100 different pathogenic mutations affecting almost every exon of the human POLG gene have been described over last years (3,4).
Regulation (affecting) of POLG
1) Confidence 0.59 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.67 Pain Relevance 0
Similarly, higher environmental temperature (25°C) used to promote glp-4(bn2) mutant phenotype also had an effect on polg-1(ok1548) mutants.
Regulation (effect) of polg-1
2) Confidence 0.43 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.68 Pain Relevance 0
Although we have detected a number of changes in polg-1 deficient worms, we were rather surprised that mtDNA depletion leaving only around 4% of mtDNA content had a rather mild phenotype in comparison with other models, where similar levels of mtDNA depletion persistently resulted in the early developmental arrest (5–7,14,31).
Regulation (changes) of polg-1 associated with helminth infection
3) Confidence 0.38 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.35 Pain Relevance 0
PEO1, which is responsible for adPEO, encodes a protein with homology to the T7 gene 4 protein (gp4) [6].
Regulation (responsible) of adPEO
4) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2579934 Disease Relevance 0.47 Pain Relevance 0
Variations in phenotypes are also seen in other adPEO families affected by the p.A475P mutation.
Regulation (affected) of adPEO
5) Confidence 0.21 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2579934 Disease Relevance 0.77 Pain Relevance 0.04

General Comments

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