INT251828

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.87
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (C10orf2) cell death (C10orf2)
C10orf2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 88.84 High High
Inflammation 7 84.72 Quite High
cytokine 1 79.40 Quite High
adenocard 2 76.72 Quite High
peripheral neuropathy 10 70.44 Quite High
depression 4 39.72 Quite Low
Hippocampus 1 16.60 Low Low
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 9 99.72 Very High Very High Very High
Parkinson's Disease 11 99.08 Very High Very High Very High
Neurodegenerative Disease 33 94.48 High High
INFLAMMATION 8 88.32 High High
Disease 126 82.56 Quite High
Liver Failure 1 73.76 Quite High
Epilepsy 1 72.16 Quite High
Peripheral Neuropathy 10 70.44 Quite High
Ataxia 14 70.24 Quite High
Voice Disorders 1 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is different from familial Parkinsonism because this patientÂ’s syndrome was due to a mutation in PEO1 [20].
Negative_regulation (mutation) of PEO1 associated with parkinson's disease and syndrome
1) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2579934 Disease Relevance 0.69 Pain Relevance 0.04
Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).
Negative_regulation (reduction) of PEO1
2) Confidence 0.15 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.63 Pain Relevance 0.07
This was further confounded by the controversies involving C0X-2 inhibitors in recent years.
Negative_regulation (inhibitors) of C0X-2
3) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 1.54 Pain Relevance 0.30

General Comments

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