INT251897

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
endothelial cells 2
Mmp8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 20 94.52 High High
Inflammation 40 80.80 Quite High
cytokine 6 70.68 Quite High
corticosteroid 1 51.84 Quite High
Inflammatory response 7 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 50 80.80 Quite High
Disease 24 78.96 Quite High
Stress 30 76.84 Quite High
Periodontal Disease 48 73.40 Quite High
Diabetes Mellitus 22 68.40 Quite High
Periodontitis 3 67.88 Quite High
Cardiovascular Disease 12 57.12 Quite High
Recurrence 1 54.16 Quite High
Metabolic Disorder 7 50.00 Quite Low
Endotoxemia 1 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of synthesis of MMP-8 and MMP-9 by endothelial cells in response to doxycycline and to a lesser extent by the chemically modified tetracyclines (CMTs) has been demonstrated at the mRNA level [56].
Negative_regulation (Inhibition) of Gene_expression (synthesis) of MMP-8 in endothelial cells
1) Confidence 0.04 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.96 Pain Relevance 0.27

General Comments

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