INT251907

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.23
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8)
proteinaceous extracellular matrix (MMP8)
MMP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 83.36 Quite High
metalloproteinase 20 70.48 Quite High
Arthritis 5 66.48 Quite High
Inflammatory response 7 25.84 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alveolar Bone Loss 1 100.00 Very High Very High Very High
Periodontal Disease 48 99.36 Very High Very High Very High
Diabetes Mellitus 22 88.16 High High
INFLAMMATION 50 83.36 Quite High
Disease 24 67.84 Quite High
Arthritis 6 66.48 Quite High
Cardiovascular Disease 12 58.40 Quite High
Stress 30 50.00 Quite Low
Metabolic Disorder 7 50.00 Quite Low
Periodontitis 3 44.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a rat model of induced periodontal disease using gingival LPS injections, elevated levels of collagenase (MMP-8), gelatinase (MMP-9), elastase and alveolar bone loss were overcome by using a synergistic combination of sub-optimal doses of the chemically modified tetracycline CMT-8 and a biphosphonate, clodronate [86]; when sub-optimal doses of these agents were used individually, there were negligible effects on the above parameters.
Negative_regulation (loss) of Positive_regulation (elevated) of collagenase associated with alveolar bone loss and periodontal disease
1) Confidence 0.00 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.23 Pain Relevance 0.26

General Comments

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