INT25192

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.08
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (GNAI1) GTPase activity (GNAI1) cytoplasm (GNAI1)
signal transducer activity (GNAI1) signal transduction (GNAI1) nucleus (GNAI1)
Anatomy Link Frequency
smooth muscle 2
neurons 2
lymphocytes 2
GNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 99.82 Very High Very High Very High
Neuritis 1 99.68 Very High Very High Very High
agonist 44 98.12 Very High Very High Very High
Opioid 67 97.84 Very High Very High Very High
Enkephalin 41 93.56 High High
antagonist 20 91.92 High High
cytokine 8 91.56 High High
Inflammation 69 91.16 High High
narcan 9 89.72 High High
Morphine 1 83.64 Quite High
Disease Link Frequency Relevance Heat
Neuritis 1 99.68 Very High Very High Very High
INFLAMMATION 74 91.16 High High
Fibromyalgia 5 89.60 High High
Targeted Disruption 3 81.08 Quite High
Bordatella Infection 3 79.16 Quite High
Fasciculation 13 77.36 Quite High
Inflammatory Pain 19 62.08 Quite High
Adhesions 16 61.16 Quite High
Increased Venous Pressure Under Development 1 58.24 Quite High
Asthma 39 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functionality, evaluated as capability to inhibit forskolin-stimulated adenylyl cyclase activity, and the level of expression of Gi proteins were investigated in peripheral blood lymphocytes.
Positive_regulation (forskolin-stimulated) of Gene_expression (expression) of Gi in lymphocytes
1) Confidence 0.49 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669173 Disease Relevance 0.09 Pain Relevance 0
FPR is known to signal through Gi proteins stimulating phospholipase C leading to mobilization of Ca2+ from intracellular stores and to activation of PI3K [24].
Positive_regulation (stimulating) of Gene_expression (proteins) of Gi
2) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.06 Pain Relevance 0.90
neurons exhibited increased neuritogenesis, extended neuritis and a two-fold increase in the number of branching points per neuron compared to wt neurons (Fig. 4g–i).
Positive_regulation (increase) of in neuron Gene_expression (neurons) of g-i in neurons associated with neuritis
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.49 Pain Relevance 0.13
also increase Gi and Gq alpha protein expression in airway smooth muscle, which could account for increased Ca2+ responses and contraction [33,34].
Positive_regulation (increase) of Gene_expression (expression) of Gi in smooth muscle
4) Confidence 0.01 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.23 Pain Relevance 0.21
This indicates that the process of down-regulation and desensitization of the delta-opioid receptor neither requires quantitative alterations in the levels of Gi and Go nor changes in the degree of coupling among their subunits.
Neg (nor) Positive_regulation (requires) of Gene_expression (levels) of Gi associated with opioid receptor
5) Confidence 0.01 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2507742 Disease Relevance 0.20 Pain Relevance 0.46

General Comments

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