INT25193

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 5.66
Pain Relevance 6.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
hepatocytes 2
plasma 1
liver 1
spinal cord 1
brain 1
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 10 100.00 Very High Very High Very High
Thermal hyperalgesia 1 99.92 Very High Very High Very High
Morphine 9 99.78 Very High Very High Very High
Spinal cord 11 99.24 Very High Very High Very High
Brush evoked pain 1 98.92 Very High Very High Very High
tolerance 3 98.48 Very High Very High Very High
Bile 247 98.36 Very High Very High Very High
hyperexcitability 2 96.08 Very High Very High Very High
Pain 21 93.00 High High
medulla 43 92.28 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.92 Very High Very High Very High
Diabetes Mellitus 327 99.16 Very High Very High Very High
Neuropathic Pain 6 98.92 Very High Very High Very High
Targeted Disruption 41 98.80 Very High Very High Very High
Fistula 76 98.56 Very High Very High Very High
Frailty 10 98.44 Very High Very High Very High
Mental Disorders 9 98.28 Very High Very High Very High
Injury 5 96.68 Very High Very High Very High
Pain 18 93.00 High High
Ganglion Cysts 1 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment at pH 4.5 did not alter basal adenylate cyclase activity but did cause a loss (50-90%) in NaF- and Gpp(NH)p-stimulated activity, indicating a functional loss of GTP-coupling proteins.
Negative_regulation (loss) of GTP
1) Confidence 0.57 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319864 Disease Relevance 0 Pain Relevance 0.12
Inhibition of the small GTP-binding protein Rac1 ameliorated post-SCI changes in spine morphology, attenuated injury-induced hyperexcitability of wide-dynamic range neurons, and progressively increased pain thresholds over a 3 d period.
Negative_regulation (Inhibition) of GTP in neurons associated with pain, injury, frailty and hyperexcitability
2) Confidence 0.57 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19052208 Disease Relevance 1.54 Pain Relevance 0.91
Reduction of the mRNA or protein levels of hepatic PEPCK was also impeded in the same group of STZ-induced diabetic rats.
Negative_regulation (Reduction) of PEPCK associated with diabetes mellitus
3) Confidence 0.44 Published 2006 Journal Diabetes Section Abstract Doc Link 16505249 Disease Relevance 0.76 Pain Relevance 0.33
Long-term opiate exposure leads to reduction of the alpha i-1 subunit of GTP-binding proteins.
Negative_regulation (reduction) of GTP associated with opiate
4) Confidence 0.41 Published 1989 Journal J. Neurochem. Section Title Doc Link 2507744 Disease Relevance 0.09 Pain Relevance 0.79
Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain.
Negative_regulation (Development) of GTP in brain associated with opiate
5) Confidence 0.41 Published 1987 Journal J. Biol. Chem. Section Title Doc Link 3036816 Disease Relevance 0.08 Pain Relevance 0.25
In spinal cord sections, chronic morphine treatment decreased DAMGO-stimulated [35S]GTP gamma S binding in laminae I and II at all levels of spinal cord examined.
Negative_regulation (decreased) of GTP in spinal cord associated with morphine and spinal cord
6) Confidence 0.41 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259753 Disease Relevance 0 Pain Relevance 1.63
The data show a very rapid downregulation of both PEPCK and G-6-Pase mRNA following the infusion of TCA in the chronic bile fistula rat (Fig. 2).
Negative_regulation (downregulation) of PEPCK in bile associated with bile and fistula
7) Confidence 0.38 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.35 Pain Relevance 0.37
Thus, the decrease in PEPCK appeared to be also related to the plasma glucose-lowering activity of tetrandrine.
Negative_regulation (decrease) of PEPCK in plasma
8) Confidence 0.34 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.18 Pain Relevance 0.41
Repeated treatment of STZ-diabetic rats with tetrandrine resulted in a marked reduction in the protein level of PEPCK to approximately 60% of that of vehicle-treated STZ-diabetic rats (Fig. 5).
Negative_regulation (reduction) of PEPCK associated with diabetes mellitus
9) Confidence 0.34 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.63 Pain Relevance 0
Similar treatment with tetrandrine reversed the elevated mRNA and protein levels of PEPCK in the liver of STZ-diabetic rats.
Negative_regulation (reversed) of PEPCK in liver associated with diabetes mellitus
10) Confidence 0.34 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC516459 Disease Relevance 0.69 Pain Relevance 0.34
The addition of TCA alone to primary rat hepatocytes in culture rapidly (1–2 h) downregulated both PEPCK (Fig. 3A) and G-6-Pase mRNA levels (Fig. 3B).
Negative_regulation (downregulated) of PEPCK in hepatocytes
11) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.21 Pain Relevance 0.21
Downregulation of PEPCK and G-6-Pase mRNA by TCA in the chronic bile fistula rat and primary rat hepatocytes
Negative_regulation (Downregulation) of PEPCK in hepatocytes associated with bile and fistula
12) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.32
(28), resulting in the downregulation of PEPCK and G-6-Pase.
Negative_regulation (downregulation) of PEPCK
13) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.28 Pain Relevance 0.14
Addition of 10 µM XTP (xanthosine triphosphate) was also shown to inhibit the GTP-CCR in Paramecium but XTP itself did not produce CCR [38].
Negative_regulation (inhibit) of GTP-CCR
14) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.12 Pain Relevance 0
This is consistent with a loss of surface GTP receptors during adaptation (desensitization).
Negative_regulation (loss) of GTP
15) Confidence 0.14 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0
Several inhibitors of sarcoplasmic/endoplasmic reticulum Ca2+-dependent ATPase (BHQ, CPA and thapsagargin) have been shown to inhibit GTP-CCR in Paramecium [55], suggesting that sequestration and/or release of Ca2+ from internal stores may be involved in the repetitive CCRs seen in response to GTP.
Negative_regulation (inhibit) of GTP-CCR in internal
16) Confidence 0.12 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.13 Pain Relevance 0.08
An ecto-ATPase is also present that may be involved in inactivation of ATP and GTP signals.
Negative_regulation (inactivation) of GTP
17) Confidence 0.10 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096533 Disease Relevance 0.10 Pain Relevance 0.03
Furthermore, cold ATP is not an inhibitor of 32P-GTP binding (while cold GTP is) and vice versa.
Negative_regulation (inhibitor) of GTP
18) Confidence 0.10 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0
Based on our findings, GTP at a dose of 500 mg per day and/or TC exercise at 3 hr/week for 24 weeks appear to be safe in postmenopausal osteopenic women.


Negative_regulation (safe) of GTP
19) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.25 Pain Relevance 0
While the effect of GTP(gammaS) was prevented by pretreatment with H7 (100 micro M), a non-selective PKA/PKC inhibitor, the fluoride-induced increase in Na(v)1.8 current was not sensitive to H7 (100 micro M), or to inclusion of deferoxamine (1 mM) in the intracellular solution.
Negative_regulation (effect) of GTP
20) Confidence 0.05 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12898089 Disease Relevance 0 Pain Relevance 0.10

General Comments

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